Words similar to gpa
Example sentences for: gpa
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In the model for the pheromone response network, NetSearch inserted Akr1p, a known inhibitor of the pheromone pathway [ 15 ] , between Ste3p and the G protein complex (Ste4p/Ste18p/Gpa1p).
It includes Far1p, a protein necessary for pheromone-induced cell cycle arrest in G1 [ 11 ] , Mpt5p, a protein necessary for recovery from cell cycle arrest [ 12 ] , and Bem1p and Sph1, both of which are necessary for establishment of cell polarity during shmooing and budding [ 13 14 ] . In our protein-interaction map there is no direct interaction between a pheromone receptor (Ste2p or Ste3p) and any component of the heterotrimeric G protein complex (Ste4p/Ste18p/Gpa1p), so NetSearch drew indirect paths through Akr1p, a known inhibitor of signaling in the pheromone pathway [ 15 ] . The predicted network does not include the GTPase Cdc42p (paths were instead drawn preferentially through its cofactor Cdc24p, which physically interacts with Ste4p) or Ste20p, because of missing interactions in the protein-interaction map.
One type of membrane-localization tag is the myristoyl group, which is attached to the glycine residue of proteins, such as S. cerevisiae Gpa1 (the α subunit of the pheromone-responsive G protein) [ 18 ] , that contain at their N-termini the sequence MGXXXS/T (where "X" can be any amino acid) [ 19 ] . Thus, we investigated whether fusion to the sequence MGCTVS, which is present at the N-terminus of Gpa1 and which we will henceforth refer to as "Myr", could restore function to the mutant versions of Boi1 that are impaired in the ability to bind phospholipid.
Our model does differ in several respects from the canonical pheromone response pathway depicted in Fig 1. It includes more members of the heterotrimeric G protein complex, including the alpha, beta, and gamma subunits, the GDP-GTP exchange factor, and the GTPase-activating protein (Gpa1p, Ste4p, Ste18p, Cdc24p, and Sst2p, respectively).
Mean Undergraduate GPA: 3.3
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