Words similar to gonadotrope
Example sentences for: gonadotrope
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The mechanisms that alter gonadotrope responsiveness to GnRH are unknown but they do not appear to be due to GnRH receptor number or LH stores in the pituitary gland [ 5 6 7 8 ] . However, the fraction of LH that is released by a maximal dose of GnRH does vary positively with gonadotrope responsiveness [ 7 ] , and elucidation of the mechanisms altering the fraction of releasable LH is likely to illuminate mechanisms of gonadotrope responsiveness to GnRH [ 44 ] .
The quantity of LH secreted by the anterior pituitary gland is the outcome of an interaction between the amount of hypothalamic GnRH secretion and the level of gonadotrope responsiveness to GnRH [ 7 ] . Quantitatively, gonadotrope responsiveness is more important than the level of GnRH secretion; for example, during the estrogen-stimulated preovulatory surge of LH secretion in the rat there is a 5-fold increase in GnRH secretion but a 50-fold increase in LH secretion [ 7 ] . Moreover, a quantity of GnRH that will evoke a normal preovulatory LH surge during the period preceding ovulation will induce only a small increase in LH secretion at other stages of the estrous cycle [ 7 ] . Similarly, termination of the preovulatory LH surge appears to be due to desensitization of the gonadotrope to GnRH action; in the sheep, a decrease in LH secretion precedes the decrease in GnRH secretion [ 41 ] , whereas in the rat, although the decrease in GnRH and LH secretion are co-incident [ 7 ] , there is evidence that the gonadotrope is already desensitized to GnRH [ 42 43 ] .
In neither case did RGS3 affect these parameters of gonadotrope function (p > 0.05).
Finally, the stronger inhibitory effect of RGS3T than RGS 3 on COS cell function was presumed to be true also for gonadotrope function and therefore was not tested here.
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