Words similar to gonadal
Example sentences for: gonadal
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Shown are the 2862 transcripts that distinguish between normal genital skin fibroblasts and gonadal fibroblasts from 46, XY female AIS patients, and between proliferating and confluent fibroblasts.
One possible interpretation of these data is that the distinct patterns of expression could have been due to differences in the origin or the developmental milieu of foreskin fibroblasts, derived from the genital tubercle, as opposed to the labial fibroblasts, derived from the genital swellings [ 10 ] . The differences in gene expression we observed in AIS fibroblasts of gonadal origin compared to those of labial origin support this view (Figure 3).
This is especially important during early embryonic development as well as in the development and function of adult tissues such as the gonadal cells (ie ovarian and testes) [ 41, 48].
In addition to the 14 genital-skin fibroblast lines used to generate the SAM list, we included five gonadal fibroblast lines from 46,XY females with complete AIS, a prostate fibroblast cell line from a normal male (analyzed twice), abdominal skin fibroblasts from a normal male, forearm fibroblasts from a normal male, and genital fibroblasts from two AIS 46,XY females who had documented AR mosaicism (ARD364, ARD 465, Table 1).
Compared to genital and gonadal fibroblasts from 46,XY females, fibroblasts from normal male genital tissues showed pronounced differences in expression of cell adhesion and extracellular matrix genes.