Words similar to genscan

Example sentences for: genscan

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To prevent any overconsolidation as a result of lack of transitional exons (in partial or complete ORFs) for adjacent genes, CpG islands, large gaps (> 50 kb) between exons and Genscan prediction were used as gene boundaries when higher-ranking boundary information was unavailable.
Unlike Releases 1 and 2, which relied heavily on Genie [ 3], Release 3 annotations did utilize GENSCAN predictions (with at least one exon with a score > 45) in the absence of other data.
Gene model splits were often necessitated by the facts that gene-prediction programs such as Genie and GENSCAN can string together genes that lie close to each other and do not resolve nested genes.
However, both Genie and GENSCAN gene models were often wrong in detail, when compared to cDNA sequence alignments for three main reasons: first, exon mis-associations: the programs placed exons from one gene with the exons of a neighboring or nested gene; second, erroneous splice site calls: the donor and acceptor sites were slightly misplaced; or third, missed mini- and micro-exons: small ORFs were not identified [ 20, 66].
In the absence of other supporting evidence for a gene, we used GENSCAN predictions only when at least one exon had a score > 45; this is a stringent threshold, as 21% of the genes in Release 3 with full-length cDNA evidence do not contain any exons scoring > 45.