Words similar to fold-change
Example sentences for: fold-change
How can you use “fold-change” in a sentence? Here are some example sentences to help you improve your vocabulary:
For the fold-change method, the expression ratios were calculated for each gene and a two-fold change was used as the criterion for significance.
The inverse also holds true, where highly expressed genes, having less error in their measured levels, may not meet an arbitrary fold-change cut-off of 2.0 even when they are truly differentially expressed [ 12 ] . Therefore, selecting differentially regulated genes based only on a single fold change across the entire range of experimental data preferentially selects lowly expressed genes [ 8 ] . This commonly used approach does not accommodate for background noise, variability, non-specific binding, or low copy numbers- characteristics typical of microarray data which may not be homogeneously distributed.
These low-intensity spots are those most aberrant in fold-change and are those for which the magnitude is adjusted most by the model of Newton et al . [ 36].
An evolving method of analysis is to define significant changes in gene expression in terms of a particular P -value after performing appropriate statistical tests that take into account the variability of gene expression data and sample size [ 6 7 8 9 10 ] . However, care must be taken to use appropriate statistical tests, P -value thresholds for significance, and sufficient n , otherwise, variance-based methods, as with less rigorous fold-change approaches, will generate high error rates.
Genes were then selected that conformed to all of the following criteria: p-value ≤ 0.001; a mean average difference value ≥ 200; fold-change ≥ 1.1 for genes increased in CC relative to normal kidney or fold-change ≤ -1.
Loading...