Example sentences for: fold-change

How can you use “fold-change” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 1) that have a 1.5 or greater fold-change to functional groups ( i.e., cell cycle, apoptosis, signal transduction, etc.) which have biological significance.

  • However, because the 'correct' fold-change limit typically shifts with decreasing intensity of expression, a fixed fold-change line is inadequate in the range of expression levels where most genes actually lie.

  • The inverse also holds true, where highly expressed genes, having less error in their measured levels, may not meet an arbitrary fold-change cut-off of 2.0 even when they are truly differentially expressed [ 12 ] . Therefore, selecting differentially regulated genes based only on a single fold change across the entire range of experimental data preferentially selects lowly expressed genes [ 8 ] . This commonly used approach does not accommodate for background noise, variability, non-specific binding, or low copy numbers- characteristics typical of microarray data which may not be homogeneously distributed.

  • We then assigned those Connections Map proteins with a 1.5 or greater fold-change to functional groups as described above.

  • To increase sensitivity, the fold-change threshold was decreased to 1.4 and the scaled signal change cut-off to 25.


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