Example sentences for: fold-change

How can you use “fold-change” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Typically, an arbitrary value for expression ratios (or fold-change values) is chosen to define significant differences in gene expression between conditions.

  • For comparison, the expression data were also filtered using an ad hoc fold-change method.

  • The inverse also holds true, where highly expressed genes, having less error in their measured levels, may not meet an arbitrary fold-change cut-off of 2.0 even when they are truly differentially expressed [ 12 ] . Therefore, selecting differentially regulated genes based only on a single fold change across the entire range of experimental data preferentially selects lowly expressed genes [ 8 ] . This commonly used approach does not accommodate for background noise, variability, non-specific binding, or low copy numbers- characteristics typical of microarray data which may not be homogeneously distributed.

  • We then assigned those Connections Map proteins with a 1.5 or greater fold-change to functional groups as described above.

  • Absolute changes in expression at different sample sizes are presented as minimum detectable fold-changes in expression using the following formula: Minimum detectable fold-change = (average expression value of the six upregulated genes in control cultures + size of the detectable difference)/average expression value of the six upregulated genes in control cultures.


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