Example sentences for: exacerbates

How can you use “exacerbates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Anti-IFN-γ treatment early in the course of disease suppresses arthritis, whereas neutralization of IFN-γ late in disease exacerbates arthritis.

  • Ioannidis doesn't define “findings,” but it seems important to attempt to separate data (“in this study 5% of people examined who lived in San Francisco from 1965–1970 developed lung cancer compared with 20% of people studied who lived in Anchorage”) from conclusions (“lung cancer rates are higher in Anchorage than San Francisco”) and hypotheses (“cold weather exacerbates the consequences of smoking”).

  • Inactivation of Cdc28 by overexpression of Sic1 suppresses multiple MEN mutants and hyperactivation of Cdc28 by overexpression of Clb2 exacerbates their phenotypes, consistent with the idea that a key function of the MEN proteins is to eradicate Cdc28 activity during the transition from anaphase/telophase to G1 [ 6 7 8 9 ] .

  • Weakened capillaries may not function optimally in the face of elevated IOP resulting in some degree of retinal ischemia that exacerbates retinal cell death.

  • Treatment with recombinant IL-10 in CIA, in proteoglycan-induced arthritis, and in experimental autoimmune encephalomyelitis reduced disease severity, and neutralizing IL-10 with antibodies exacerbated disease [ 19 20 22 23 ] . The present data are consistent with previous results and show that a complete absence of IL-10 exacerbates inflammation in CIA [ 37 38 39 ] . The anti-inflammatory properties of IL-10 suggest that endogenous IL-10 may function as a regulator of proinflammatory mediators in vivo [ 39 ] . It is interesting, however, that disease severity inversely correlates with the levels of IFN-γ in IL-10 -/-mice, suggesting that IL-10 may control disease activity via regulating IFN-γ responses.


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