Words similar to er-resident

Example sentences for: er-resident

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Two highly conserved responses are observed under conditions of endoplasmic reticulum (ER) stress; the ER overload and unfolded protein responses [ 24 25 ] . The unfolded protein response is characterized by generalized suppression of protein synthesis and the specific induction of ER-resident proteins and GADD153 [ 24 ] . The transcription factor nuclear factor kB is activated during the ER overload response, leading to the downstream induction of pro-inflammatory proteins [ 25 ] . Therefore, the transcriptional modulation of GADD153 and IkB by mefloquine suggests that the ER might be a target of the drug.
Compromised ER function (induced by numerous stressors including depletion of ER calcium stores) may lead to the accumulation of unfolded proteins in the ER [ 11 ] . These events may trigger the UPR, in which the transcription of genes encoding ER-resident chaperones is upregulated.
In contrast to this relationship, when the experiment clustering was performed on genes encoding ER-resident proteins, the effects of zinc starvation were most similar to those inflicted by DTT and diamide (Figure 8d), suggesting that zinc limitation may initiate the UPR.