Example sentences for: er-negative

How can you use “er-negative” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Estrogen and progesterone, which stimulate the growth of breast epithelium, are two crucial hormones involved not only in normal breast development but also in carcinogenesis of breast epithelium and progression of breast cancer [ 28 ] . About 40% of breast cancers are ER-negative [ 28 ] . ER-negative tumors are unresponsive to anti-estrogen therapy, probably because of constitutive growth factor expression [ 28 29 ] . In general, these tumors have a higher histologic grade and a higher proliferative rate and are associated with poorer prognosis [ 28 ] . The finding that 100% of ER-negative tumors expressed BP1 might therefore be highly relevant to both the prognosis and therapy of those difficult-to-treat tumors.

  • 2. All of the tumors shown are ER-negative and PR-negative.

  • These data demonstrate a statistically significant association between the expression of the transcription factor BP1, not previously implicated in breast cancer, and ER-negative breast tumors.

  • 0 months for Caucasian patients and 8.9 months for African American patients [ 30 31 ] . African American women also have a higher risk of ER-negative tumors after adjustment is made for stage and age at diagnosis.

  • BP1 expression was significantly more prevalent in ER-negative tumors, of which 100% were BP1-positive, compared with ER-positive tumors, of which 73% were BP1-positive ( P = 0.03).


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