Example sentences for: epistatic

How can you use “epistatic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The abnormal genetic architecture of inbred strains and the fixation of multiple alleles that affect fitness will almost inevitably produce unusual pleiotropic and epistatic effects on a range of complex traits.

  • 3. Upon exposure to a trans-silencer locus, certain Arabidopsis transgenes display an alteration in their epistatic interaction with other transgenes.

  • Using whole bacteria and viruses, several studies have sought to measure the mutational decay function for fitness and the overall direction of epistatic interactions [ 25 26 27 28 56 ] . Only one of these studies found net synergistic interactions [ 56 ] . Several other studies with bacteria and viruses have documented widespread compensatory mutations [ 57 58 59 ] , although these studies all used selection to find compensatory mutations rather than directly estimating their frequency.

  • Recent work has shown that epistatic interactions can be interpreted as curvature in the fitness surface [ 6 ] , which implies that geometry imposes limitations on the types of epistasis that can be observed for any given genotype.

  • Because an exact exponential decay means that the average effect of a new mutation is independent of how many mutations have accumulated previously, β is a measure of the net effect of epistatic interactions.


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