Words similar to episomal
Example sentences for: episomal
How can you use “episomal” in a sentence? Here are some example sentences to help you improve your vocabulary:
'Diffuse' signals (indicative of episomal HPV), 'diffuse' and 'punctate', or 'punctate' signals alone were demonstrated amongst pre-invasive lesion samples (Figure 2A,2Band 2C).
GAL1 promoter in a centromeric or episomal plasmid, respectively, indirect immunofluorescence of HA-Ppt1p or direct fluorescence from EGFP-Ppt1p showed that both proteins were also localized throughout the cell.
[ 13 ] . HPV was not detected by the assay in basal/parabasal cells of (non-condylomatous) CIN I lesions (> 30 examined; unless HPV-16 positive [ 2 ] ) suggesting low-copy number episomal HPV was not detectable and indicating a limit to the sensitivity of the assay.
These observations are consistent with earlier studies that a punctate signal is representative of integration and a diffuse signal of episomal HPV, and with the theory that integration is an important factor in lesion progression [ 2 12 ] . The data suggest the optimized method may be useful in screening CIN lesions for integration.
If this is the case, then punctate signal detected in carcinomas and high-grade CIN lesions may only represent integration of multiple copies of HPV at sites within the genome, and low-copy episomal (or integrated) DNA may remain sub-threshold on archival FFPE samples.
Loading...