Words similar to episomal

Example sentences for: episomal

How can you use “episomal” in a sentence? Here are some example sentences to help you improve your vocabulary:

These observations are consistent with earlier studies that a punctate signal is representative of integration and a diffuse signal of episomal HPV, and with the theory that integration is an important factor in lesion progression [ 2 12 ] . The data suggest the optimized method may be useful in screening CIN lesions for integration.
A possible explanation maybe that that ~8 kilo-base single/low-copy episomal HPV sequences may be subject to relatively more degradation and loss from tissues during routine processing than HPV DNA that is physically integrated into the human chromosome (~50 - 250 mega-base pairs).
[ 13 ] . HPV was not detected by the assay in basal/parabasal cells of (non-condylomatous) CIN I lesions (> 30 examined; unless HPV-16 positive [ 2 ] ) suggesting low-copy number episomal HPV was not detectable and indicating a limit to the sensitivity of the assay.
The demonstration of 1-2 copies of integrated HPV DNA detected as punctate signal begs the question as to why single/low-copy episomal HPV is not also detectable as punctate signal.
If this is the case, then punctate signal detected in carcinomas and high-grade CIN lesions may only represent integration of multiple copies of HPV at sites within the genome, and low-copy episomal (or integrated) DNA may remain sub-threshold on archival FFPE samples.