Words similar to epistasis

Example sentences for: epistasis

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Yet, this correlation does not explain the overall preponderance of antagonistic epistasis observed in two computational systems [ 2 11 ] , nor the absence of overall synergistic epistasis in most biological systems that have been carefully studied in this regard.
Mutations whose effects are independent of one another are termed multiplicative . If mutations interact so that their combined effect on fitness is greater than expected from their individual effects, then epistasis is said to be synergistic . For deleterious mutations, synergistic epistasis means that the decline in average fitness accelerates as more random mutations are added (such epistasis is termed negative by Phillips et al.
By contrast, if a sequence is located at the periphery of a high-fitness cluster, or in a region of low density of high-fitness sequences, then this synergistic tendency is lessened, and we might even observe antagonistic epistasis for this sequence.
. Antagonistic epistasis therefore implies unexpected robustness to the effects of multiple deleterious mutations [ 2 ] .
Thus, a high cross-validationconsistency (~10) lends support to that SNP being important forthe epistasis model.