Words similar to epistasis

Example sentences for: epistasis

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Mutations whose effects are independent of one another are termed multiplicative . If mutations interact so that their combined effect on fitness is greater than expected from their individual effects, then epistasis is said to be synergistic . For deleterious mutations, synergistic epistasis means that the decline in average fitness accelerates as more random mutations are added (such epistasis is termed negative by Phillips et al.
Recent work has shown that epistatic interactions can be interpreted as curvature in the fitness surface [ 6 ] , which implies that geometry imposes limitations on the types of epistasis that can be observed for any given genotype.
The removal of compensatory mutations causes a pronounced upward shift of β toward more synergistic epistasis.
Table 4shows the power todetect the two functional SNPs for GPNN and the BPNN using 100 datasets for each of the five epistasis models with both the two functionaland eight non-functional SNPs in the analyses.
Such an interplay would complicate the overall pattern of directional epistasis relative to regulatory complexity.