Example sentences for: enzymes

How can you use “enzymes” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It has been documented that a variety of proteolytic enzymes produced by malignant epithelial cells could have substantial impacts on the physical integrity or functions of the subjacent ME cells and the basement membrane [ 30 31 32 ] . In contrast, ME cells could influence the biological behavior of subjacent epithelial cells.

  • Although imatinib inhibits different kinases in various diseases (BCR-ABL in CML, KIT or PDGFR-alpha in gastrointestinal stromal tumors [GISTs], and PDGFR-alpha in hypereosinophilic syndrome [HES]) (reviewed in [14]), some tumors that become refractory to treatment with imatinib appear to have analogous secondary mutations in the kinase-coding domain of the genes encoding these three enzymes.

  • To combat these enzymes, β-lactamase inhibitors such as clavulanic acid, sulbactam, and tazobactam have been given in combination with a β-lactam containing antibiotic to treat bacterial infections [ 52 ] . One class of β-lactamases that are particularly unaffected by the known β-lactamase inhibitors and have been shown to hydrolyze almost all known β-lactam containing antibiotics including late generation carbapenems at high rates are the metallo-β-lactamases [ 14 15 16 17 18 19 ] . Although there are no reports of metallo-β-lactamases isolated from major pathogens [ 51 53 ] , these enzymes are produced by pathogens such as B. fragilis, S. maltophilia, and P. aeruginosa.

  • After multiple iterations, a PSI-BLAST search using the E. coli GshB (gi121663) as an initial query sequence found 509 sequences of enzymes in the ATP-grasp superfamily, to which the bacterial enzyme is known to belong, but no eukaryotic GshB sequences.

  • The activity of the mitochondrial respiratory chain enzymes, although mostly below the normal mean, was within the normal range in skeletal muscle with moderate increase (52%) in the activity of citrate synthase suggesting mitochondrial proliferation (Table 1).


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