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Example sentences for: enhances
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Released NF-κB dimers then translocate to the nucleus, bind to its cognate DNA elements, and induce the expression of target genes [ 23 24 25 ] . Activated, nuclear translocated, NF-κB transcription factor has been documented in the mouse embryo from the 1-cell stage onward [ 26 27 ] . Activated NF-κB translocation into the nucleus, directly or indirectly, effects the transcriptional control of over 150 target genes [ 28 ] . NF-κB enhances cell proliferation by stimulating the expression of cytokines such as TNF, IL-1, IL-2, IL-6, and IL-8, among others [ 28 29 ] ; NF-κB inhibits apoptosis by inducing TRAF and clAP expression which suppresses Caspase 8 activation [ 30 ] , and by inhibition of p53 transactivation [ 31 32 ] .
M6P/IGF2R is normally imprinted in mice with only the maternal copy of the gene being expressed [ 41 ] . In contrast, both copies of the M6P/IGF2R are expressed in humans because genomic imprinting at this locus was lost in the primate lineage approximately 75 million years ago [ 42 ] . Importantly, restoration of biallelic M6P/IGF2R expression in mice results in a marked reduction in offspring weight late in embryonic development that persists into adulthood [ 43 ] . This demonstrates that M6P/IGF2R allelic loss or haploid insufficiency markedly enhances cell proliferation and/or survival during fetal development.
Like the AR, Stat3 enhances all three other SHRs tested in the presence of the corresponding hormone (Dex for GR, R5020 for PR, or E 2 for ER) (Fig.
For instance, coexpression of type II BMPR with either IA or IB BMPR increases ligand-binding affinity and dramatically enhances biologic activity [ 11].
The wealth of verbatim quotations--constituting a good third of this book--also enhances Burn Rate 's verisimilitude.
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