Words similar to enhancers
Example sentences for: enhancers
How can you use “enhancers” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our algorithm Argos for predicting enhancers from raw genomic sequence works astonishingly well.
More recently, transgenic mice have also been used to express Cre recombinase to mediate the conditional deletion of loxP -flanked DNA sequences in specific cell types in vivo . Traditional methods for generating transgenic mice require the availability of well characterized transcriptional regulatory elements, promoters or enhancers, that direct transgene expression in specific cell types.
These include 1) the strength of the 3' and 5' splice sites, which can be calculated using the consensus values that were determined by Shapiro and Senepathy [ 5 ] or by the Splice Site Prediction program by Neural Networks (SSPNN, http://www.fruitfly.org/seq_tools/splice.html) which takes more known sequences into account, 2) the branch point sequences and 3) certain sequences such as exonic splicing enhancers (ESE) that can activate the use of a weak 3' splice site or elements such as exonic splicing silencer elements (ESS) that inhibit splicing [ 1 ] . In addition to these cis -acting elements, exon length [ 6 ] and secondary structure have also been mentioned to play a role in splicing [ 7 ] .
These experiments showed that enhancers deleted for each of the ~50-bp stretches within the enhancer were nevertheless capable of stimulating core ars3002 . Thus, none of the ~50-bp stretches within the enhancer is essential for enhancer activity.
Using CNCS clusters to identify enhancers represents the comparative genomic analogue of efforts to predict cis -regulatory sequences by exploiting the clustering of predicted transcription factor binding sites [ 70, 71].
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