Words similar to enhancer
Example sentences for: enhancer
How can you use “enhancer” in a sentence? Here are some example sentences to help you improve your vocabulary:
In fact, CNCS clusters may be a powerful source of data for inferring transcription factor specificity, as specific binding-site motifs are likely to be locally over-represented in CNCS clusters with demonstrable enhancer function.
3bshows that when these same deletions were assayed in the absence of the enhancer (so overall replication efficiency was much lower), each deletion significantly reduced transformation frequency [ 10].
Among genes that are stimulated by FSH/cAMP during the period of maturation of Sertoli cells (15 to 20 days of age in rats), are several subunits of cAMP-dependent protein kinase (PKA), the serine/threonine kinase mainly responsible for the downstream effects of FSH [ 15 ] . Expression of the RIIβ regulatory subunit of cAMP-dependent protein kinase is highly induced (50-fold) at the mRNA level in primary cultures of rat Sertoli cells as a late response to cAMP peaking at 12 hours [ 16 ] . We have demonstrated that expression of CAAT/Enhancer binding protein β (C/EBPβ) is induced by cAMP with rapid kinetics in Sertoli cells, and that C/EBPβ is responsible for induction of late response genes like the RIIβ-gene [ 17 ] . The RIIβ promoter contains a conserved E-box/HLH element in the basal promoter localized at -280 to -275 relative to the functional ATG [ 18 ] . This element is shown to be important for cAMP-responsiveness in granulosa cells, and it has been shown to bind both USF and Myc in CHO and NB2a cells [ 18 19 ] . In this work, we show that USF isoforms may regulate cAMP responsiveness of the RIIβ promoter by modulating the effect of C/EBP, and that the formation of USF isoforms may be regulated by cAMP in Sertoli cells.
Region 16 is the ~50-bp region whose deletion most affects enhancer activity (Fig.
3aalso indicate that there is considerable sequence redundancy within the enhancer itself.
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