Words similar to ecm
Example sentences for: ecm
How can you use “ecm” in a sentence? Here are some example sentences to help you improve your vocabulary:
This is the first demonstration that treatment of wounds with a pro-inflammatory and angiogenic chemokine accelerates development of the granulation tissue during healing by stimulating the precocious deposition of ECM molecules that are critical for proper healing.
The defects in Bmp4 mutant mice may involve abnormal cell-cell adhesion, cell migration, and/or delayed or abnormal differentiation of mesenchymal cells in the iridocorneal angle, including decreased production of ECM.
For instance, IL-1-degraded cartilage tissues and cell suspensions are frequently employed as model systems to study cartilage metabolism under osteoarthritis-like conditions [ 1 2 3 4 ] and to assess the efficacy of various drug therapies [ 5 6 7 8 9 ] . IL-1 signals cells via cell surface receptors to upregulate proteases, matrix metalloproteinases and aggrecanase, while downregulating matrix metalloproteinase inhibition and proteoglycan synthesis [ 10 11 ] . The ultimate effect of these metabolic changes include damage to the ECM, loss of ECM components (especially proteoglycan), and alteration of the normal balance of catabolic and anabolic processes that regulate cartilage ECM composition.
In order to follow both the differentiation of fibroblasts into myofibroblasts and their apoptosis in relation to the tension in the surrounding ECM, we utilized two-color FACS analyses.
The ability of cancer cells to proliferate within a tissue depends on their response to adhesive and growth factor cues within the ECM [ 10 ] , and self-sufficiency in growth signals is one of the hallmarks of cancer [ 11 ] . To stimulate their own growth and proliferation in tissue, tumor cells can overproduce and release their own growth factors or obtain them from the matrix as they are released by matrix metalloproteinases [ 12 ] . The endothelial vasculature grows into the tumor and provides nutrients and oxygen [ 13 ] . This model is illustrated by the experimental results presented here, as both A549 (lung) and U118 (brain) cell lines are observed to upregulate one set of genetic programs related to cell growth and proliferation when in culture and another set related to cell adhesion, the extracellular matrix, growth substances, and neovascularization when developing as an in vivo tumor.
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