Words similar to ecs
Example sentences for: ecs
How can you use “ecs” in a sentence? Here are some example sentences to help you improve your vocabulary:
To better understand molecular mechanisms and pathways of EC activation, we embedded ECs in 3D type I collagen in presence or absence of human recombinant VEGF 165.
To confirm that the genes identified by SSHDD encode proteins, we performed Western blot analysis of total cellular protein isolated from ECs grown in monolayers.
Intracellular signaling machinery of adenylyl cyclase is required for cytoskeletal organization, vessel maturation, and vessel integrity [ 24 ] . PF4 is a chemokine that binds to FGF and is a known inhibitor of EC proliferation and migration [ 25 ] . Thus, the upregulation of PF4 might limit the degree of activation of ECs and morphogenic differentiation.
Mediators known to activate ECs include inflammatory cytokines, growth factors such as VEGF/VPF and basic fibroblast growth factor (bFGF), extracellular matrix (ECM) proteins such as collagen and fibronectin, and proteases such as MMPs [ 1 2 ] . In vitro and in vivo assays indicate that VEGF signaling promotes increased permeability, cell migration, proliferation, and differentiation, functioning through two EC-specific tyrosine kinase receptor such as Kinase domain receptor (KDR) [ 1 2 3 ] . In the majority of solid tumors, VEGF is upregulated in response to hypoxia, inducing the expression of pro-angiogenic genes that promote tumor angiogenesis, growth and eventual metastasis [ 3 4 5 ] . The expression of both positive and negative factors must be tightly and specifically regulated in a coordinated manner.
The identification of VEGFR-1 and VEGFR-2 (KDR) was consistent with the observation that the stimulation of ECs with VEGF increases the expression of VEGFR-2, promoting myocardial revascularization [ 22 ] . We also detected the cell adhesion molecules VCAM-1, VE-Cadherin, and the α 2 integrin subunit, all known regulators of angiogenesis.
Loading...