Words similar to ebpβ
Example sentences for: ebpβ
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When CMV-LAP (which encodes p35-C/EBPβ) is transfected with GAL4-SRF and the reporter construct, we see a 7-fold increase in CAT activity that is potentiated to 75-fold when activated Ras is cotransfected.
Therefore, C/EBPβ is a target of a Ras-dependent signaling pathway that regulates its interaction with SRF.
Our lab has previously shown that p35-C/EBPβ activates an SRE-driven reporter construct while p20-C/EBPβ inhibits serum stimulation of the same reporter [ 22].
C/EBP is previously reported to be an important accessory factor for transactivation by several other transcription factors [ 26 ] . C/EBPβ was shown to transactivate the α1-acid glycoprotein gene promoter even when mutated in the DNA-binding domain, and this activation appeared to depend on protein-protein interaction with glucocorticoid receptor through the leucine zipper region [ 27 ] . Recently, a conserved domain in C/EBPα and C/EBPβ was shown to mediate cAMP responsiveness, strengthening the fact that C/EBP may be characterized as a cAMP-responsive nuclear regulator [ 28 29 ] . On the COX-2 promoter in granulosa cells, cAMP-mediated regulation was shown to be mediated primarily by an E-box that bind USF1 and USF2 isoforms in a manner resembling the RIIβ E-box in Sertoli cells [ 30 ] . Transactivation of the COX-2 gene in skin carcinoma cells is highly dependent on this E-box together with a C/EBP binding site that bind C/EBPβ and C/EBPδ [ 31 ] . These data strengthens a model of formation of a cAMP-responsive unit (CRU) containing USF and C/EBP.
These results suggest a cooperative role between the TCF and C/EBPβ transcription factors in regulation of the c-fos SRE in response to Ras-dependent signaling pathways.
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