Words similar to ebpα
Example sentences for: ebpα
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This retention of GHFT1-5 cells in the G1 and S phases of the cell cycle occurred for both the transcriptionally active C/EBPα-GFP and inactive GFP-C/EBPα fusions.
CDK2, and other proteins, also interact with another domain of C/EBPα [ 25 ] required for proliferation arrest (discussed below).
Candidate mechanisms for the block of proliferation by C/EBPα include 1) activation of the gene promoters of the cyclin-dependent kinase inhibitor p21 [ 37 ] , gadd45 [ 5 6 ] , gas2 and gas3 [ 38 39 ] , 2) post-transcriptional stabilization of p21 [ 22 ] , or 3) interactions of C/EBPα with cell cycle proteins including p21 [ 22 24 25 55 ] , CDK2 [ 25 36 ] , CDK4 [ 36 ] , retinoblastoma [ 54 ] , the retinoblastoma-related protein p107 [ 34 ] and the G1/S-regulating E2F transcription complex [ 26 33 ] (Fig.
In cultured cells, C/EBPα expression leads to decreased colony formation upon antibiotic selection [ 23 24 25 ] , decreased DNA synthesis [ 22 24 25 26 27 ] and an enhanced proportion of cells in the G1 phase of the cell cycle [ 26 ] . Thus, C/EBPα regulates cellular proliferation, as well as gene transcription.
It was previously suggested that the peri-centromeric targeting of C/EBPα was a function of DNA binding: C/EBPα binding sites are concentrated within the repeated DNA sequences that comprise the bulk of peri-centromeric chromatin [ 49 ] . Indeed, C/EBPα truncated to contain little more than the DNA binding, bZIP domain still concentrated at peri-centromeric chromatin [ 45 ] . By contrast, C/EBPα deleted of amino acids 310 to 358 (Fig.
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