Words similar to ebpα

Example sentences for: ebpα

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Hoechst 33342 stains AT-rich DNA that concentrates around the centromeres [ 45 49 ] . Given the role of the centromere as a checkpoint for regulation of the mitotic phase of the cell cycle [ 50 51 ] , it was hypothesized that C/EBPα localization around the centromere could play a role in C/EBPα regulation of the cell cycle [ 49 ] .
Different C/EBPα domains were required for G1- and S-phase arrest.
The independence of C/EBPα-induced proliferation arrest from C/EBPα-regulated transcriptional activation also has been observed in other studies [ 25 26 ] . Thus, simple transcription activation mechanisms do not account for the effect of C/EBPα on the cell cycle.
C/EBPα binds to and inhibits transcriptional activation by E2F [ 26 33 ] . The complex of E2F with the retinoblastoma-related p107 protein is prevalent in cycling cells.
These domains interact with p21, CDK2 and CDK4 [ 22 24 25 36 55 ] . Thus, C/EBPα interactions with at least p21 and CDK4 were not required for the anti-proliferative actions of C/EBPα in GHFT1-5 cells.