Words similar to ebpα
Example sentences for: ebpα
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C/EBP is previously reported to be an important accessory factor for transactivation by several other transcription factors [ 26 ] . C/EBPβ was shown to transactivate the α1-acid glycoprotein gene promoter even when mutated in the DNA-binding domain, and this activation appeared to depend on protein-protein interaction with glucocorticoid receptor through the leucine zipper region [ 27 ] . Recently, a conserved domain in C/EBPα and C/EBPβ was shown to mediate cAMP responsiveness, strengthening the fact that C/EBP may be characterized as a cAMP-responsive nuclear regulator [ 28 29 ] . On the COX-2 promoter in granulosa cells, cAMP-mediated regulation was shown to be mediated primarily by an E-box that bind USF1 and USF2 isoforms in a manner resembling the RIIβ E-box in Sertoli cells [ 30 ] . Transactivation of the COX-2 gene in skin carcinoma cells is highly dependent on this E-box together with a C/EBP binding site that bind C/EBPβ and C/EBPδ [ 31 ] . These data strengthens a model of formation of a cAMP-responsive unit (CRU) containing USF and C/EBP.
Synchronization facilitated characterization of the cell cycle stages blocked or prolonged by C/EBPα expression.
2C) by eliminating the leucine zipper required for DNA binding by all members of the bZIP family of transcription factors [ 52 ] . Thus, as predicted [ 49 ] , the bZIP domain is necessary and sufficient for C/EBPα targeting to peri-centromeric chromatin.
When cells were blocked in G1 by mimosine treatment, C/EBPα expression caused no decrease in the proportion of cells in G2/M (Fig.
Tang and Lane [ 49 ] showed that C/EBPα becomes associated with peri-centromeric chromatin upon expression during adipocyte differentiation.
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