Words similar to ebpα

Example sentences for: ebpα

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The GFP-C/EBPα vector was constructed by inserting the cDNA encoding the S65T derivative of GFP [ 57 ] at the start codon of the cDNA encoding rat C/EBPα.
In pituitary cells, C/EBPα is part of a multi-subunit complex [ 41 42 ] that activates the growth hormone [ 42 ] and prolactin [ 43 44 ] promoters.
C/EBPα binds to and activates transcription of the gene promoter for the p21 inhibitor of cyclin-dependent kinase (CDK) [ 37 ] . This led to speculation that p21 gene activation may contribute to cell cycle arrest by C/EBPα [ 37 ] . Similarly, suppression of mitotic growth during adipocyte differentiation was associated with C/EBPα activation of the promoters of gadd45 (growth arrest and DNA damage-inducible gene 45), gas2 and gas3 (growth arrest-associated genes 2 and 3) [ 5 6 38 39 ] . However, C/EBPα mutants defective in DNA binding still blocked proliferation [ 25 33 ] . This suggested that direct promoter activation was unnecessary, or redundant, for C/EBPα proliferation arrest [ 18 ] .
G1 block in GHFT1-5 cells required C/EBPα amino acids 1-97 (Fig.
The independence of C/EBPα-induced proliferation arrest from C/EBPα-regulated transcriptional activation also has been observed in other studies [ 25 26 ] . Thus, simple transcription activation mechanisms do not account for the effect of C/EBPα on the cell cycle.