Words similar to ebpβ-mediated

Example sentences for: ebpβ-mediated

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3. Overexpression of USF2, but not USF1, inhibits cAMP-mediated and C/EBPβ-mediated induction of the RIIβ promoter.
An inhibitory effect of USF on Myc-mediated cellular proliferation has been demonstrated in HeLa cells [ 33 ] , and a non-canonical HLH element inhibits expression of the fibroblast growth factor binding protein (FGF-BP) in several carcinoma cells [ 34 ] . Furthermore, USF2 inhibits binding of hypoxia-inducible factor-1 (HIF-1) to the plasminogen activator inhibitor -1 (PAI-1) gene in hepatocytes in order to disturb transcriptional activation [ 35 ] . Our results add C/EBPβ-mediated activation of RIIβ to the mechanisms inhibited by USF.
Co-transfecting USF1 had no significant effect on C/EBPβ-mediated induction, but USF2a (1:1, USF2a:C/EBPβ expression vectors) reduced induction by 60%, indicating that USF2a may interrupt the ability of C/EBPβ to transactivate the RIIβ promoter.
Our present results indicate that USF2 disturbs this C/EBPβ-mediated transactivation of RIIβ.
We have previously reported that some of the late induction of RIIβ by cAMP depends on the rapid cAMP-mediated increase in C/EBPβ expression [ 17 ] . To test the effect of different USF isoforms on C/EBPβ-mediated induction of the RIIβ promoter, we transfected combinations of the transcription factors (Fig.