Words similar to dominant-suppressors

Example sentences for: dominant-suppressors

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Amino acid substitutions in the N(T)KxD motif cause a drastic reduction in the affinity of Ras-related GTPases for guanine nucleotides [ 35 36 ] . When overexpressed in cultured cells, these mutant GTPases function as dominant-suppressors of their endogenous counterparts [ 26 27 31 ] , presumably because they can compete for interaction with effectors, exchange factors or docking proteins, but cannot cycle on and off membranes in a nucleotide-dependent manner.
An extensive body of published work supports the notion that Rab proteins bearing mutations in the N(T)KxD nucleotide binding motif function as dominant-suppressors of their endogenous cellular counterparts.