Words similar to dominant-positive

Example sentences for: dominant-positive

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In summary, here we describe the use of a mutant Syk construct to produce a dominant-positive effect on endogenous Syk activation in the absence of BCR engagement.
The specific target for this dominant-positive effect remains to be identified.
RCH carried out the biochemical experiments to characterize the dominant-positive effect and its influence on signal transduction, and drafted the manuscript.
found that transfection of a mutant Syk expression construct carrying only the 3F alteration into a T cell lines could overcome the need for TCR occupancy for IL-2 expression in PMA-treated cells [ 62 ] . However, since the mutant Syk used retained kinase activity, these studies could not distinguish between a gain-of-function effect versus a dominant-positive effect as found here.
It is likely that the replacement of the three carboxy-terminal tyrosine residues with phenylalanine is necessary for the dominant-positive phenotype.