Words similar to dominant-positive

Example sentences for: dominant-positive

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The specific target for this dominant-positive effect remains to be identified.
BCR-induced interaction between Cbl and Syk increases the susceptibility of Syk to proteolysis [ 55 ] , possibly through enhancement of ubiquitination [ 56 ] . Expression of a dominant-negative SHP-1 phosphatase in the mature murine B cell line K46 resulted in an increase in BCR-induced Syk kinase activity as measured by C3b phosphorylation in an ICKA and enhanced BCR-induced Ca 2+fluxes [ 57 ] . It remains to be determined if interference with any of these known regulatory proteins is responsible for the dominant-positive effect.
found that transfection of a mutant Syk expression construct carrying only the 3F alteration into a T cell lines could overcome the need for TCR occupancy for IL-2 expression in PMA-treated cells [ 62 ] . However, since the mutant Syk used retained kinase activity, these studies could not distinguish between a gain-of-function effect versus a dominant-positive effect as found here.
It is likely that the replacement of the three carboxy-terminal tyrosine residues with phenylalanine is necessary for the dominant-positive phenotype.
In summary, here we describe the use of a mutant Syk construct to produce a dominant-positive effect on endogenous Syk activation in the absence of BCR engagement.