Words similar to dominant-positive

Example sentences for: dominant-positive

How can you use “dominant-positive” in a sentence? Here are some example sentences to help you improve your vocabulary:

RCH carried out the biochemical experiments to characterize the dominant-positive effect and its influence on signal transduction, and drafted the manuscript.
It is likely that the replacement of the three carboxy-terminal tyrosine residues with phenylalanine is necessary for the dominant-positive phenotype.
The presence of a dominant-positive effect under these conditions suggests that the Syk kinase is kept inactive in resting cells by an active suppression mechanisms, which is disrupted by the presence of the (K395A/3F)Syk mutant.
BCR-induced interaction between Cbl and Syk increases the susceptibility of Syk to proteolysis [ 55 ] , possibly through enhancement of ubiquitination [ 56 ] . Expression of a dominant-negative SHP-1 phosphatase in the mature murine B cell line K46 resulted in an increase in BCR-induced Syk kinase activity as measured by C3b phosphorylation in an ICKA and enhanced BCR-induced Ca 2+fluxes [ 57 ] . It remains to be determined if interference with any of these known regulatory proteins is responsible for the dominant-positive effect.
In summary, here we describe the use of a mutant Syk construct to produce a dominant-positive effect on endogenous Syk activation in the absence of BCR engagement.