Words similar to dominant
Example sentences for: dominant
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the dominant provider.
By comparison FS mRNA was highly expressed in all the GC of the dominant follicles over the cycle (Table 1, Fig.
Unambiguous evidence for a cosuppression of transgene and endogene, as opposed to a dominant negative effect of the transgenic protein, has previously been shown for line L4 and others [ 27 ] , and COP1 endogene suppression was also associated with GFP-COP1 silencing in T2 generation type C lines (not shown).
We have previously demonstrated the overexpression and hormone-independent activation of the IGF-IR in primary breast cancers [ 42 ] . Similar overexpression of the IGF-IR and the ligands IGF-I and IGF-II have been seen in human gliomas and astrocytomas [ 43 44 45 46 ] . Because of the important role for the IGF-IR in cell survival, we investigated whether a dominant negative IGF-IR could inhibit growth of the U87 glioma.
Mutations in TMC1 are responsible for the autosomal dominant human hearing disorder DFNA36 and for the recessive deafness DFNB7/11 [ 5 ] ; the corresponding murine gene Tmc1 also causes deafness in the mutant mouse strains Beethoven ( Bth ) and deafness ( dn ) [ 6 ] . Bth / Bth mice display altered potassium currents in early postnatal cochlear hair cells, in particular Ik,n and Ik,f currents appear to be depressed [ 10 ] . This observation led to the hypothesis that Tmc1 may participate directly or indirectly in regulating the permeability of potassium channels [ 10 ] . Because of the high level of conservation of the amino acid sequences among the eight mammalian TMC proteins (Figure 1, Additional file 1), we speculate that other TMC proteins may as well be modifiers of ion channels or transporters.
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