Words similar to dominant-negative

Example sentences for: dominant-negative

How can you use “dominant-negative” in a sentence? Here are some example sentences to help you improve your vocabulary:

Mutant molecules that inhibit the activation or function of the wildtype counterpart in the same cell have been defined as dominant-negative molecules.
The deposition of newly synthesized fibrillin into the matrix was greatly reduced (13 % of normal), however, suggesting that the internally deleted mutant fibrillin-1 molecules are secreted and exert a dominant-negative effect on extracellular microfibril assembly.
Thus, the question of whether the nuclear inclusions containing the D123I and T120A mutants are caused by dominant-negative suppression of endogenous Rab24 function remains to be resolved.
We attempted to distinguish between these possibilities by using an alternative strategy to make a dominant-negative form of Rab24.
BCR-induced interaction between Cbl and Syk increases the susceptibility of Syk to proteolysis [ 55 ] , possibly through enhancement of ubiquitination [ 56 ] . Expression of a dominant-negative SHP-1 phosphatase in the mature murine B cell line K46 resulted in an increase in BCR-induced Syk kinase activity as measured by C3b phosphorylation in an ICKA and enhanced BCR-induced Ca 2+fluxes [ 57 ] . It remains to be determined if interference with any of these known regulatory proteins is responsible for the dominant-positive effect.