Words similar to dominant-negative

Example sentences for: dominant-negative

How can you use “dominant-negative” in a sentence? Here are some example sentences to help you improve your vocabulary:

One gene in this region, slimb , is an interesting candidate because this gene encodes an F-box protein that is part of an SCF complex [ 26 ] [ 29 ] . Several independent alleles of slimb were tested and all enhanced the dominant-negative mCul1 overexpression phenotype (fig.
Mutant molecules that inhibit the activation or function of the wildtype counterpart in the same cell have been defined as dominant-negative molecules.
The most obvious is that it provides a mechanism for generating embryos that express alleles that are predicted, or known, to be detrimental to normal embryonic development, for example dominant-negative or gain-of-function alleles.
Previous studies have shown that Rab24 exhibits several unusual characteristics that distinguish it from other members of the Rab GTPase family [ 25 ] . The studies described in this report demonstrate that putative dominant-negative mutant forms of Rab24, bearing single amino acid substitutions in the conserved N(T)KxD nucleotide binding motif ( e.g. , D123I and T120A), are targeted to numerous inclusion bodies that disrupt the nuclear envelope and enter the nuclear compartment.
In the present study we set out to learn about the biological function of Rab24 by using a well-established paradigm in which a dominant-negative Rab construct is expressed in cultured cells, anticipating that it will suppress the trafficking step(s) mediated by its endogenous counterpart.