Example sentences for: dominant-negative

How can you use “dominant-negative” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Confirmatory studies with other potential dominant-negative mutants, such as those bearing substitutions at the position cognate to Ras S17, were not possible with Rab24, because such mutants remained in the GTP state.

  • However, the Src inhibitor, PP1 or the expression of a dominant-negative Src mutant, will reduce GPCR-mediated transphosphorylation of the EGFR and GPCR-mediated ERK activation to varying degrees (partial to total), suggesting that at least two different tyrosine kinases can be involved [ 18 ] . Src was found to co-immunoprecipitate with the phosphorylated EGFR in COS-7 cells exposed to either LPA or EGF [ 14 ] . These authors reported that the autophosphorylation of Y350 in the EGFR does not occur after LPA exposure, suggesting that c-Src is the principal tyrosine kinase in this instance and not the EGFR's intrinsic tyrosine kinase.

  • In the present study we set out to learn about the biological function of Rab24 by using a well-established paradigm in which a dominant-negative Rab construct is expressed in cultured cells, anticipating that it will suppress the trafficking step(s) mediated by its endogenous counterpart.

  • We attempted to distinguish between these possibilities by using an alternative strategy to make a dominant-negative form of Rab24.

  • One gene in this region, slimb , is an interesting candidate because this gene encodes an F-box protein that is part of an SCF complex [ 26 ] [ 29 ] . Several independent alleles of slimb were tested and all enhanced the dominant-negative mCul1 overexpression phenotype (fig.


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