Words similar to dominant-negative

Example sentences for: dominant-negative

How can you use “dominant-negative” in a sentence? Here are some example sentences to help you improve your vocabulary:

One gene in this region, slimb , is an interesting candidate because this gene encodes an F-box protein that is part of an SCF complex [ 26 ] [ 29 ] . Several independent alleles of slimb were tested and all enhanced the dominant-negative mCul1 overexpression phenotype (fig.
The most obvious is that it provides a mechanism for generating embryos that express alleles that are predicted, or known, to be detrimental to normal embryonic development, for example dominant-negative or gain-of-function alleles.
To explore this issue further, we attempted to generate another potential dominant-negative form of Rab24, predicted to be locked in the GDP state.
Thus, the question of whether the nuclear inclusions containing the D123I and T120A mutants are caused by dominant-negative suppression of endogenous Rab24 function remains to be resolved.
The deposition of newly synthesized fibrillin into the matrix was greatly reduced (13 % of normal), however, suggesting that the internally deleted mutant fibrillin-1 molecules are secreted and exert a dominant-negative effect on extracellular microfibril assembly.