Example sentences for: dominant-negative

How can you use “dominant-negative” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • One gene in this region, slimb , is an interesting candidate because this gene encodes an F-box protein that is part of an SCF complex [ 26 ] [ 29 ] . Several independent alleles of slimb were tested and all enhanced the dominant-negative mCul1 overexpression phenotype (fig.

  • Mutant molecules that inhibit the activation or function of the wildtype counterpart in the same cell have been defined as dominant-negative molecules.

  • The most obvious is that it provides a mechanism for generating embryos that express alleles that are predicted, or known, to be detrimental to normal embryonic development, for example dominant-negative or gain-of-function alleles.

  • Previous studies have shown that Rab24 exhibits several unusual characteristics that distinguish it from other members of the Rab GTPase family [ 25 ] . The studies described in this report demonstrate that putative dominant-negative mutant forms of Rab24, bearing single amino acid substitutions in the conserved N(T)KxD nucleotide binding motif ( e.g. , D123I and T120A), are targeted to numerous inclusion bodies that disrupt the nuclear envelope and enter the nuclear compartment.

  • In the present study we set out to learn about the biological function of Rab24 by using a well-established paradigm in which a dominant-negative Rab construct is expressed in cultured cells, anticipating that it will suppress the trafficking step(s) mediated by its endogenous counterpart.


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