Words similar to dominant-negative

Example sentences for: dominant-negative

How can you use “dominant-negative” in a sentence? Here are some example sentences to help you improve your vocabulary:

To explore this issue further, we attempted to generate another potential dominant-negative form of Rab24, predicted to be locked in the GDP state.
The deposition of newly synthesized fibrillin into the matrix was greatly reduced (13 % of normal), however, suggesting that the internally deleted mutant fibrillin-1 molecules are secreted and exert a dominant-negative effect on extracellular microfibril assembly.
Since neither Rab24(S22N) nor Rab24(S67Q) showed evidence of being locked in a GDP-bound state, it is unlikely that either would function as a dominant-negative.
Mutant molecules that inhibit the activation or function of the wildtype counterpart in the same cell have been defined as dominant-negative molecules.
In the present study we set out to learn about the biological function of Rab24 by using a well-established paradigm in which a dominant-negative Rab construct is expressed in cultured cells, anticipating that it will suppress the trafficking step(s) mediated by its endogenous counterpart.