Words similar to dominant-negative
Example sentences for: dominant-negative
How can you use “dominant-negative” in a sentence? Here are some example sentences to help you improve your vocabulary:
Mutant molecules that inhibit the activation or function of the wildtype counterpart in the same cell have been defined as dominant-negative molecules.
The algorithm described above was applied to a microarray experiment designed to compare gene expression in human cells harboring either a cadherin-derived inhibitor (Cad5CD) of the β-catenin pathway, or a dominant-negative Tcf inhibitor (TcfDN) of the pathway [ 7 8 ] . The biological interpretation of the results will be presented elsewhere (Pierce and Kamb, unpublished).
This may be important for examining the effects of expressing gain-of-function or dominant-negative alleles of a gene product.
A partial cDNA clone homologous to AtCOP1 has been previously identified in mammals, containing all three conserved protein-protein interaction domains [ 20 ] . Remarkably, when expressed in plant cells, the mammalian COP1-reporter fusion protein exhibited a light-regulated nuclear localization pattern similar to AtCOP1 [ 20 ] . Although mammalian COP1 failed to rescue the Arabidopsis cop1 mutants, over-expression of the amino-terminal half of mammalian COP1 in Arabidopsis caused a dominant-negative phenotype, resembling the effect of over-expressing the corresponding fragment of AtCOP1 [ 20 21 ] .
Previous studies have shown that Rab24 exhibits several unusual characteristics that distinguish it from other members of the Rab GTPase family [ 25 ] . The studies described in this report demonstrate that putative dominant-negative mutant forms of Rab24, bearing single amino acid substitutions in the conserved N(T)KxD nucleotide binding motif ( e.g. , D123I and T120A), are targeted to numerous inclusion bodies that disrupt the nuclear envelope and enter the nuclear compartment.
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