Words similar to dendrite-promoting
Example sentences for: dendrite-promoting
How can you use “dendrite-promoting” in a sentence? Here are some example sentences to help you improve your vocabulary:
To address the former question, we tested the ability of follistatin and noggin to block the dendrite-promoting activity of BMP-5.
Noggin and follistatin, soluble proteins known to function as physiological antagonists for BMP-7 [ 21 ] , also inhibit the dendrite-promoting activity of BMP-5.
BMP-5 signaling may be modulated by noggin and follistatin since these BMP antagonists were observed to inhibit the dendrite-promoting activity of BMP-5.
For example, follistatin binds both activin and BMP-7 avidly but competes weakly or not at all with the type I receptor for BMP-4 binding [ 25 45 ] , whereas noggin binds to BMPs -2 and -4 with greater affinity than BMP-7 [ 46 ] . Whether BMP-5 function can be antagonized by noggin or follistatin has not been previously reported, but our results suggest that simultaneous addition of either antagonist with BMP-5 significantly inhibits the dendrite-promoting activity of BMP-5 in a concentration-dependent manner.
These data are consistent with conclusions from previous studies indicating that dendrite-promoting activity is restricted to BMPs from the 60A or dpp (BMPs 2 and 4) subgroups and is not observed with BMPs from other subgroups such as BMP-3, BMP-13 or dorsalin, or with other members of the TGF-β superfamily such as activin, TGF-β1, -β2 or -β3 [ 16 17 ] . Functional redundancy between BMPs of the 60A subgroup has been previously reported with respect to other developmental endpoints [ 6 ] , of which some, such as upregulation of cell adhesion molecules [ 30 ] , may be directly relevant to effects on dendritic growth.
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