Words similar to deletions
Example sentences for: deletions
How can you use “deletions” in a sentence? Here are some example sentences to help you improve your vocabulary:
Because deletions of stretches of ~50 bp within the enhancer had no effects on transformation frequency and only mild effects on colony size (Fig.
However, some of the deletions (Δ16-Δ20) moderately reduce colony size, indicating that each of the corresponding regions (16-20) makes a modest unique contribution to enhancer activity.
3 region to which RASSF1A maps undergoes deletions in many solid tumor types, including GCTs [ 9 ] . RASSF1A encodes a splice variant of human RAS effector homologue, which interacts with the XPA protein and functions as a negative regulator of cell growth [ 16 17 ] . RASSF1A has been shown to be inactivated by promoter methylation in a variety of tumor types [ 16 17 18 19 ] . The 17q21 and 17p13 regions, to which BRCA1 and HIC1 map, respectively, also have been characterized by high frequency of LOH in GCT [ 9 ] . The BRCA 1 gene plays critical roles in DNA repair and recombination, cell cycle checkpoint control, and transcription and has been shown to be hypermethylated in breast-ovarian cancer [ 4 ] . The HIC1 gene is also often hypermethylated in many human cancers [ 20 21 22 ] . The DNA repair gene MGMT encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 23 ] . Epigenetic inactivation of the MGMT gene was reported in a wide variety of cancers [ 24 25 ] . Also, a low frequency of methylation of the APC , RARB , and FHIT genes was detected in NSGCTs.
Several of their deletions overlap the deletions we report.
Here, we have identified two sites of candidate tumor suppressor genes and confirmed the previous reports that the 5p deletions occur in a small proportion of precancerous lesions.
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