Example sentences for: deletions

How can you use “deletions” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In all three patients, we found EGFR mutations associated with drug sensitivity (all exon 19 deletions).

  • APC mutations have been identified in medulloblastoma cell lines and up to 4% of sporadic medulloblastomas [ 16 17 ] . Furthermore, point mutations or small deletions in β- catenin exon 3 have been identified in 5-10% of sporadic medulloblastomas and in supratentorial primitive neuroectodermal tumors (PNETs) [ 17 18 19 ] . Finally, large deletions in AXIN were recently found in 12% of sporadic medulloblastomas [ 20 ] . In the absence of Wnt signaling β-catenin is sequestered in the cytoplasm, and nuclear translocation of β-catenin has been used to monitor activation of the Wnt pathway in a number of different tumor types.

  • Generation of double and triple deletions within the enhancer region

  • However, some of the deletions (Δ16-Δ20) moderately reduce colony size, indicating that each of the corresponding regions (16-20) makes a modest unique contribution to enhancer activity.

  • Based on the follow-up studies, we suggested that 5p genetic deletions might identify high-risk lesions for progression to invasive cancer [ 7 ] . In a more recent study it was also shown that the 5p deletions were significantly more frequent in dysplasias that were recurrent compared to non-recurrent dysplasias [ 9 ] . These data therefore suggest that 5p genetic alterations occur early in cervical carcinogenesis and they may be critical to the development of invasive cancer.

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