Example sentences for: deleterious

How can you use “deleterious” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Although adaptation by natural selection depends on occasional beneficial mutations, in fact most mutations are neutral or deleterious.

  • But as the distance away from this peak increases, a portion of the mutant distribution may move into the vicinity of one or more other fitness peaks, separated from the original one by a valley of deleterious mutations.

  • Mutations whose effects are independent of one another are termed multiplicative . If mutations interact so that their combined effect on fitness is greater than expected from their individual effects, then epistasis is said to be synergistic . For deleterious mutations, synergistic epistasis means that the decline in average fitness accelerates as more random mutations are added (such epistasis is termed negative by Phillips et al.

  • The N-terminal deletion alleles have higher levels of constitutive expression relative to the C-terminal mutations and have overall higher levels of protein expression; one explanation is that the C-terminal mutations are deleterious.

  • Activation of TNF-RI and other death domain containing receptors of the TNF receptor superfamily have been shown to cause an efflux of GSH, which contributes to the apoptotic process [ 42 61 ] . Provision of GSH in the present study reduced the deleterious effects of TNFα on CLENDO cells.


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