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Example sentences for: defective

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Moreover, all five clones were defective for TK activity compared with HSV-1 SC16 in a 3H-thymidine kinase assay (Table 4).
When different binding site lesions are introduced into the two subunits, thereby creating a mutant-mutant heterodimer, several outcomes are possible: If, for example, one lesion affects half-site A and the other affects half-site B, one of the RNA-binding sites is doubly defective, but the other is left intact.
First, defective tolerance from skewed X inactivation should only be directed at X-linked antigens that are polymorphic, and for which the individual is heterozygous.
Net1 is unlikely to directly regulate transmission of the tester chromosome, because it is only localized to rDNA in the nucleolus [ 15 16 17 ] . Thus, the difference between net1 tab 2-1and CDC14 TAB 6-1presumably results from molecular defects unique to the former mutant, including defective nucleolar structure and function, or perhaps defective nuclear transport ( [ 18 ] ; Figure 6).
The reduced expression of these cytokines in Hoxa3 +/- Pax1 -/-compound mutants could be an indirect effect of defective TEC differentiation, or could be direct downstream targets since both Hoxa3 and Pax1 are expressed in fetal thymus [ 54 55 ] . Comparison of the Hoxa3 +/- Pax1 -/-phenotype with those of cytokine mutants do not reveal many similarities [ 30 46 56 57 58 59 60 61 ] , probably because of the simultaneous reductions in multiple cytokines in the Hoxa3 +/- Pax1 -/-mutants.