Words similar to defective

Example sentences for: defective

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This was demonstrated previously by artificially removing the prosequence of one β subunit and showed that the assembly of this β subunit is completely blocked while separate expression of the prosequence was enough to restore the assembly [ 19 ] . The defective assembly of a β subunit due to the lack of prosequence is illustrated in Fig.
Our results provide direct genetic evidence for these functions of TECs, by showing that these processes are defective in mutants with a primary TEC differentiation defect (the Hoxa3,Pax1 compound mutants).
The accumulation of non-secreted protein in mutants defective in ER to Golgi transport leads to proliferation of the ER [ 37 44 ] . The membrane proliferation seen by TEM in npa1-1/sec23 and npa2-1/sec13 cells (Figure 4) and the coincident mislocalization of Nups (Figure 3and data not shown) prompted us to test if Nups were accumulating at the ER.
Moreover, he had found another problem: The speedometer was defective.
In comparison to our previous genetic screen with a strain expressing only GFP-Nup49p [ 26 ] , these results suggest that increasing the number of GFP-Nups as reporters for NPC integrity effectively increases the likelihood of obtaining a panel of mutants defective in global NPC assembly, stability, and localization.