Example sentences for: defect

How can you use “defect” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Further investigation revealed an autosomal-dominant inherited defect in the anticoagulant function of factor V resulting in resistance to the anticoagulant action of activated protein C (APC) [ 18].

  • The WP and the LAT both hint at a manufacturing defect as a potential cause.

  • Cystic fibrosis (CF) is a generalized exocrine disease resulting from the defective regulation of epithelial chloride ion transport within various organ systems, most importantly the lungs [ 1 2 3 4 ] . This dysfunction can arise from a variety of mutations within the cystic fibrosis transmembrane conductance regulator (CFTR) gene on chromosome 7, which encodes the transmembrane pump responsible for regulating transepithelial ion levels [ 1 2 4 ] . This defect is associated with an increased viscosity of the airway surface fluid, and according to some studies, an altered salt concentration [ 5 6 ] . These and other pleiotropic effects of the CF gene abnormality increase the susceptibility of CF patients to bronchopulmonary bacterial infection by opportunistic pathogens.

  • The B cell antigen receptor (BCR) signaling defect is very severe such that XLA patients have a block in the pro-B to pre-B cell transition and consequently have no mature B cells.

  • pJC15 arrays and pJC14 arrays induced similar migration defects, so the sequence from the Bgl II to the Hpa I restriction sites did not appear to contribute to the migration defect.


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