Words similar to cysteines
Example sentences for: cysteines
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This dual CXXC motif, found in MoeB, ThiF, and HesA proteins, forms a metal center with a zinc atom [ 7 9 ] . The presence of all four of these cysteines has been shown to be required for activity in MoeB).
Finally, both the sterolin-1 and sterolin-2 are cysteine-rich proteins (16 cysteines in sterolin 1 and 14 in sterolin 2), five of these cyteines in sterolin-1 are present in the extracellular loop containing the mutation.
The hyperthermophilic topoisomerase I from Thermotoga maritima has been shown to coordinate one Zn(II) with a unique tetracysteine motif Cys-X-Cys-X 16 -Cys-X-Cys but Zn(II) binding is not required for relaxation activity [ 33 ] . The sequence of this unique tetracysteine motifs is somewhat different from those present in other type IA topoisomerases in that the other tetracysteine motifs always had at least two amino acids separating the pairs of cysteines (Cys-X 2-11 -Cys), instead of just one amino acid (Cys-X-Cys) in T. maritima topoisomerase I [ 33 ] . Therefore the structure and function of the single Zn(II) binding motif in T. maritima may differ from the multiple Zn(II) binding motifs in E. coli topoisomerase I. Direct interaction between DNA and the T. maritima Zn(II) binding motif has not been demonstrated.
From this, we conclude that at least one of the three cysteines in pR is probably modified post-translationally.
The triple cysteine mutant (pR-TCM) has all three of its native cysteines (Cys-107, Cys-156, and Cys-175) replaced with serines, and was prepared using the same E. coli expression system and purification methods as the wild type.
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