Words similar to cyclazocine
Example sentences for: cyclazocine
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The rank order of potency of these ligands was; etorphine>lofentanil≥cyclazocine=xorphanol>met-enkephalin> Win 44,441=hydromorphone≥butorphanol>metazocine=SKF 10047> dezocine≥ nalbuphine>morphine>fentanyl.
Louis, MO), nalbuphine and β-endorphin were obtained from RBI (Natik, MA), cyclazocine, etorphine, metazocine, morphine, nalorphine, and SKF 10047 were obtained from National Institute of Drug Abuse (Bethesda, MD), lofentanil was from Janssen Pharmaceutical Inc. (Titusville, NJ), Dezocine was from Wyeth Laboratories (Philadelphia, PA), Win 444,441 was from Sterling Winthrop Pharmaceutical and Xorphanol was from Miles Inc.
The most potent ligands studied, as measured by the lowest IC 50 values (Table 1), were etorphine, cyclazocine, lofentanil, and xorphanol with IC 50 's of less than 10 nM.
All ligands were dissolved in distilled water except cyclazocine, dezocine, etorphine, which were dissolved in 100% ethanol.
Finally the four weakest agonists, cyclazocine, dezocine, metazocine and xorphanol all exhibited efficacies that showed statistically significant difference when compared to fentanyl (p < 0.01), and thus were categorized as partial agonists.