Example sentences for: cyclases

How can you use “cyclases” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Classic adenylyl and guanylyl cyclases show a far more sporadic distribution, and are often present in multiple copies fused to a variety of signaling domains such as the cyclic nucleotide binding domains [ 24 ] . Cyclic nucleotide generating activity is not known to exist in a subset of the archaea [ 25 ] , though most of them contain a well-conserved copy of the CYTH domain.

  • Using sensitive sequence profile comparison methods, we show that the CyaB-like adenylyl cyclases are homologs of the soluble mammalian thiamine triphosphatases [ 17 ] , and they define a novel superfamily of enzymes that utilize ATP and other organic phosphates.

  • At convergence, this search detected, in addition to the soluble guanylyl cyclases from the animals, several bacterial proteins, including certain methyl-accepting chemotaxis receptors from bacteria such as Desulfovibrio and Clostridium . Transitive searches initiated with the small bacterial proteins that entirely correspond to the N-terminal-most domain of the SGCs also recovered the same set of proteins as observed in the earlier search, with e <.01.

  • They are likely to function as sensors of diffusible gaseous ligands that activate at least three distinct, downstream signaling pathways: namely phosphotransfer through the two-component systems, methyl ester-dependent chemotactic response and cyclic nucleotide signaling through the diguanylate cyclases/phosphodiesterases.

  • Using sequence profile searches we identify two conserved domains in the N-terminal extensions of the soluble guanylyl cyclases from animals.


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