Words similar to cyclase
Example sentences for: cyclase
How can you use “cyclase” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our results clearly characterize the ligands studied as agonists or antagonists at μ opioid receptors with respect to inhibition of adenyly cyclase.
Activation of the ionic current was induced by preincubation of AQP1-expressing oocytes for 10-30 minutes in 10 mM 8Br-cGMP (Sigma) in high K +saline, containing (in mM): 30 KCl, 80 K gluconate, 5 MgCl 2 , 5 HEPES, pH 7.3, or by addition of 2-4 mM sodium nitroprusside (SNP), a stimulator of guanylate cyclase and cGMP production [ 34 35 ] . Control oocytes treated in the same conditions showed no induction of an ionic current.
Although β-adrenoceptor desensitization [ 23] or reduced ATPase activity [ 25] may account for the decrease in basal heart rate in the hypertrophied male hearts, the increased sensitivity to isoproterenol may support the hypotheses of ischemia-induced activation of β-adrenoceptor kinase [ 26] or modulation of G-protein signaling to preserve adenylate cyclase activity [ 27].
A well established method for assessing G-protein activation by opioid receptors and characterizing activity of opioid ligands is measuring the extent of inhibition of forskolin-stimulated adenylyl cyclase (AC) activity [ 12 13 14 21 22 23 ] . Adenylyl cyclase has been implicated in playing a role in mediating the analgesic effect of opioid ligands through μ opioid receptors [ 24 25 26 27 28 ] . Thus, characterizing the ability of opioid ligands to inhibit cAMP production, such as described in this report, could be used as an index for assessing their activity as a correlate of their analgesic effects.
This compound selectively inhibits mammalian PLC, but has no direct effect on bacterial PLC, bacterial or mammalian phospholipase A 2 or adenylyl cyclase [ 14 ] . U73343, a structural analogue of U73122 that differs by only one double bond, has no direct effect on PLC and is commonly used as a negative control.
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