Example sentences for: cyclase

How can you use “cyclase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • On the other hand, it has been previously demonstrated that direct activation of adenylate cyclase by Forskolin or cholera toxin, inhibition of cAMP-specific phosphodiesterase, and treatment with a cell permeable cAMP analog, induces a rise in intracellular cAMP [ 22 23 24 25 26 ] . Since cAMP is known to modulate the expression of CD8 in mice [ 27 ] , we sought to determine whether cAMP-dependent protein kinase (PKA)-mediated signaling plays a role in modulating the mRNA levels of CD3, CD4, and CD8 in ex vivo examined human thymocytes.

  • gi: 17229771, e = 10 -4in iteration 1) and a diguanylate cyclase from Rhodobacter sphaeroides (gi: 22958462 e = 10 -3in iteration 3).

  • Based on these two sets of results, if the analgesic effect of butorphanol is mediated via μ opioid receptors through the inhibitory effect of these receptors on adenylyl cyclase, the equal efficacy of morphine and butorphanol would support an equal antinociceptive effect of these two drugs.

  • This compound selectively inhibits mammalian PLC, but has no direct effect on bacterial PLC, bacterial or mammalian phospholipase A 2 or adenylyl cyclase [ 14 ] . U73343, a structural analogue of U73122 that differs by only one double bond, has no direct effect on PLC and is commonly used as a negative control.

  • These include: a Hh-protein-blocking antibody, 5E1 [ 23 ] ; a natural product derivative, cyclopamine [ 9 10 ] that has recently been shown to act downstream of Ptc, perhaps at the level of Smo [ 11 ] ; a recently identified synthetic small-molecule inhibitor, Cur61414, which has inhibitory properties similar to cyclopamine [ 17 ] ; and forskolin, an adenylate cyclase/protein kinase A activator that is thought to block Hh signaling by stimulating degradation of members of the Gli family of transcriptional activators [ 2 ] .


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