Words similar to cyclase
Example sentences for: cyclase
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As in the pheromone response and cell wall integrity network models, key components of the Ras GTPase are included, such as Cdc25p (the Ras guanine nucleotide exchange factor), Cyr1p (the Ras-associated adenylate cyclase), and Srv2p, which enables the activation of adenylate cyclase by Ras2p.
Genes encoding practically all the solo versions of the HNOB domain occur in the same predicted operon as a histidine kinase or a GGDEF domain (diguanylate cyclase) [ 33 34 35 ] . In some cases these operons also encode receiver domain proteins of the two component systems, PP2C phosphatases or cyclic diguanylate phosphodiesterases (Fig.
Experimental analysis on the Methanococcus CyaB homolog revealed no adenylyl cyclase activity comparable to that seen in Aeromonas CyaB [ 16 ] . Likewise, there is no evidence for a widespread presence of the ThTPase activity in the organisms that contain CYTH domain proteins [ 17 ] . Hence, the principal biological function of the CYTH domains may be different from those of the experimentally characterized members of this family.
Intracellular signaling machinery of adenylyl cyclase is required for cytoskeletal organization, vessel maturation, and vessel integrity [ 24 ] . PF4 is a chemokine that binds to FGF and is a known inhibitor of EC proliferation and migration [ 25 ] . Thus, the upregulation of PF4 might limit the degree of activation of ECs and morphogenic differentiation.
Metabotropic glutamate receptors (mGluRs) are a family of class 3 G protein-coupled receptors with important functions in the regulation of synaptic transmission, plasticity, neuronal excitability, and the regulation sensory transduction [ 1 2 3 4 5 ] . The eight mGluRs (mGluR1-8) and their splice variants have been divided into three groups (I-III) based on sequence homology, pharmacology and G protein coupling profiles [ 3 6 7 ] . Group II (mGluR2 and 3) and III (mGluR4, and 6 through 8) couple negatively to adenylate cyclase through activation of the G i/o family of G proteins [ 8 ] . Group I mGluRs (mGluR1 and 5) couple to multiple G proteins in native and heterologous systems, and have been observed to couple to G q/11 , G i/o and/or G s [ 9 10 11 12 13 14 15 ] . mGluRs appear to be important mediators of synaptic transmission in the brain.
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