Words similar to cyclase
Example sentences for: cyclase
How can you use “cyclase” in a sentence? Here are some example sentences to help you improve your vocabulary:
3shows that the signal, which regulates the expression of human CD8, is cAMP-mediated, since direct activation of adenylate cyclase by cholera toxin produced the same effects as the di-butiryl cAMP analog.
In order to understand the evolutionary affinities and provenance of the CyaB adenylyl cyclase from Aeromonas hydrophila , we carried out database searches using sensitive sequence profile analysis methods.
Metabotropic glutamate receptors (mGluRs) are a family of class 3 G protein-coupled receptors with important functions in the regulation of synaptic transmission, plasticity, neuronal excitability, and the regulation sensory transduction [ 1 2 3 4 5 ] . The eight mGluRs (mGluR1-8) and their splice variants have been divided into three groups (I-III) based on sequence homology, pharmacology and G protein coupling profiles [ 3 6 7 ] . Group II (mGluR2 and 3) and III (mGluR4, and 6 through 8) couple negatively to adenylate cyclase through activation of the G i/o family of G proteins [ 8 ] . Group I mGluRs (mGluR1 and 5) couple to multiple G proteins in native and heterologous systems, and have been observed to couple to G q/11 , G i/o and/or G s [ 9 10 11 12 13 14 15 ] . mGluRs appear to be important mediators of synaptic transmission in the brain.
Experimental analysis on the Methanococcus CyaB homolog revealed no adenylyl cyclase activity comparable to that seen in Aeromonas CyaB [ 16 ] . Likewise, there is no evidence for a widespread presence of the ThTPase activity in the organisms that contain CYTH domain proteins [ 17 ] . Hence, the principal biological function of the CYTH domains may be different from those of the experimentally characterized members of this family.
NO is released by a cell through the action of the nitric oxide synthase (NOS) on its substrate, the amino acid arginine [ 20 ] . NO diffuses through the neighboring cells and elicits its functions by activating a soluble guanylyl cyclase (SGC) that synthesizes cGMP using GTP as a substrate [ 16 18 ] . The animal SGCs are dimeric enzymes comprised of two homologous subunits, α and β.
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