Example sentences for: cxcr
How can you use “cxcr” in a sentence? Here are some example sentences to help you improve your vocabulary:
Biotinylated mouse anti-human CCR1 monoclonal antibody (mAb), mouse anti-human CCR2 mAb conjugated with phycoerythrin (PE), mouse anti-human CCR6 mAb conjugated with PE, mouse anti-human CXCR1 mAb conjugated with PE, mouse anti-human CXCR2 mAb conjugated with PE, mouse anti-human CXCR5 mAb conjugated with PE, mouse anti-human CCR3 mAb conjugated with FITC, mouse anti-human MCP-1 mAb (24822.
Approximately 2 × 10 6of H9 or H9/Tat cells, and 5 × 10 6PBMC cells were infected with either an HXB-2 (CXCR4, T-tropic), or BaL (CCR5, Macrophage-tropic) at 5 ng of p24 gag antigen/ HIV-1 strain.
The cysteinyl leukotrienes (CysLT), LTC, LTD, and LTE, were first shown to be essential mediators in asthma [ 29 ] . However, when the mouse leukotriene B4 receptor (m-BLTR) gene, was cloned it was shown to have significant sequence homology with chemokine receptors (CCR5 and CXCR4), co-receptors for many different HIV-1 clades [ 30 ] . Along the same lines, when cells were infected with 10 primary clinical isolates of HIV-1, leukotriene B4 receptor was primarily utilized for efficient entry into cells which were mainly of the syncytium-inducing phenotype [ 31 ] . Therefore, up-regulation of neuropeptide Y-like receptor and down-regulation of leukotriene B4 receptor in Tat expressing cells indicates a selective advantage of one class of virus (CCR5) over another (CXCR4).
In addition, there was a significant negative association between CXCR3 expression on lung T cells and the percent of predicted forced expiratory volume in 1 s (FEV1), based on an R 2 goodness-of-fit statistic of 0.27 (Figure 2C; p = 0.0089, r = −0.
Such activity was reported for dextran sulfate after 2 h incubation with HIV-1 [ 2 ] but results of other studies indicated that dextran sulfate failed to neutralize virus infectivity [ 4 10 ] . Inactivation of HIV-1 by carrageenan was reported in a review article [ 18 ] . BufferGel is virucidal against HIV-1 by providing a buffered low pH environment (pH 3.9 [ 25 ] ), but virus inactivation might be incomplete and possibly compromised by minor pH increases due to the presence of seminal fluid [ 40 ] . To be effective in preventing infection by direct virus inactivation, anti-HIV-1 microbicides must be virucidal against both X4 and R5 viruses, utilizing CXCR4 and CCR5 as coreceptors [ 39 41 ] , respectively, R5 HIV-1 being most frequently sexually transmitted.
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