Example sentences for: cxc
How can you use “cxc” in a sentence? Here are some example sentences to help you improve your vocabulary:
SDF-1 is a powerful CXC chemokine that recruits circulating lymphocytes, monocytes, and CD34 +hematopoietic progenitors, but not neutrophils [ 39, 40].
Several observations support the assertion that a complex interaction between IL-8 and several other growth factors, cytokines, or other proteins is responsible for these tumor-related events [ 5 9 10 11 12 13 ] . Growth regulated protein alpha (GRO-α), beta (GRO-β), and ENA-78 have been reported to be co-induced with IL-8 in A549 cells stimulated with two proinflammatory cytokines, IL-1β and TNF-α [ 14 ] . This result is consistent with the presence of nuclear factor kappa B (NF-κB) consensus binding sites in the promoter regions of all three genes [ 4 15 ] . In addition, GRO-α and -β are also members of the ELR +CXC cytokine family that are reported to be important mediators of tumorigenesis through their angiogenic properties [ 2 16 ] . They both share one of the IL-8 receptors, CXCR2, which has been postulated to regulate the ELR +CXC chemokine-mediated angiogenesis and resulting-tumorigenesis [ 1 ] . These observations suggest that GRO-α and -β may exhibit expression profiles similar to IL-8.
MIG/CXCL 9 and IP-10/CXCL10 are glutamine-leucine-arginine (ELR)-negative CXC chemokines that are potent chemoattractants for activated T cells [ 11 12 13 ] . These chemokines also have in common the ability to signal through a G protein-coupled receptor, CXCR3, expressed on activated T lymphocytes.
The chemotactic cytokines, or chemokines, compose a large superfamily of small structurally related polypeptides that play important roles in host defense by recruiting specific subsets of leukocytes to sites of inflammation and injury [ 6 ] . Chemokines have been associated with a number of inflammatory diseases and conditions, including asthma, sepsis, inflammatory bowel disease, and adult respiratory distress syndrome [ 7 8 9 ] . The chemokine superfamily can be divided into two major groups based on the position of the first two of four-conserved cysteine residues at the amino terminus, which are either adjacent (CC subfamily) or separated by one amino acid (CXC subfamily).
Interleukin-8 (IL-8) is a potent member of the supergene family of CXC chemokines with ELR motif (ELR+).
Loading...