Example sentences for: cxc
How can you use “cxc” in a sentence? Here are some example sentences to help you improve your vocabulary:
The CXC chemokine IL-8 does not bind to CCR5.
The chemotactic cytokines, or chemokines, compose a large superfamily of small structurally related polypeptides that play important roles in host defense by recruiting specific subsets of leukocytes to sites of inflammation and injury [ 6 ] . Chemokines have been associated with a number of inflammatory diseases and conditions, including asthma, sepsis, inflammatory bowel disease, and adult respiratory distress syndrome [ 7 8 9 ] . The chemokine superfamily can be divided into two major groups based on the position of the first two of four-conserved cysteine residues at the amino terminus, which are either adjacent (CC subfamily) or separated by one amino acid (CXC subfamily).
Interleukin-8 (IL-8) is a potent member of the supergene family of CXC chemokines with ELR motif (ELR+).
In the granulation tissue of burn wounds, expression of groα /MGSA and CXCR2 (the receptor for MGSA) was associated with fibroblasts, smooth muscle cells/myofibroblasts and a subpopulation of macrophages [ 7 ] . Groα/MGSA and IL-8 have also been shown to enhance re-epithelialization of human skin grafts in chimeric mice [ 29 38 ] . It has also been found that several CXC chemokines can modulate angiogenesis [ 39 ] , a process that is critical for proper healing.
Several observations support the assertion that a complex interaction between IL-8 and several other growth factors, cytokines, or other proteins is responsible for these tumor-related events [ 5 9 10 11 12 13 ] . Growth regulated protein alpha (GRO-α), beta (GRO-β), and ENA-78 have been reported to be co-induced with IL-8 in A549 cells stimulated with two proinflammatory cytokines, IL-1β and TNF-α [ 14 ] . This result is consistent with the presence of nuclear factor kappa B (NF-κB) consensus binding sites in the promoter regions of all three genes [ 4 15 ] . In addition, GRO-α and -β are also members of the ELR +CXC cytokine family that are reported to be important mediators of tumorigenesis through their angiogenic properties [ 2 16 ] . They both share one of the IL-8 receptors, CXCR2, which has been postulated to regulate the ELR +CXC chemokine-mediated angiogenesis and resulting-tumorigenesis [ 1 ] . These observations suggest that GRO-α and -β may exhibit expression profiles similar to IL-8.
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