Example sentences for: cpla
How can you use “cpla” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although there is no inhibition of [Ca 2+] i release by U0126 and little effect on Ser 505phosphorylation, it is possible that MEK1 inhibition by U0126 prevents cPLA 2 translocation by another mechanism.
cPLA 2 is regulated by controlling its cellular localization and access to membrane-phospholipid substrate.
Analysis of the increase in fluorescence at the Golgi with respect to time demonstrates that the rates of translocation of cPLA
1 cells, without constitutively active ERKs, AA release is delayed after [Ca 2+] i mobilization, and is temporally correlated with ERK activation [ 40 ] , whereas in MDCK cells with constitutively active ERKs, AA release is rapid, with significant AA release measured 30 s after [Ca 2+] i increase [ 15 ] . This temporal correlation between AA release and ERK activation has also been reported in CHO cells in response to PAF stimulation [ 35 41 ] . These results support the observations made here that ERK activity is required for phospholipid hydrolysis independently of cPLA 2 translocation.
cPLA 2 translocates primarily to Golgi in response to a transient [Ca 2+] i changes and to Golgi and ER in response to a sustained [Ca 2+] i increase [ 15 ] . The reduction in AA release by MEK inhibition did not involve a failure in [Ca 2+] i release or translocation.
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