Words similar to cpla

Example sentences for: cpla

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As previously reported [ 22 ] , the cPLA 2 S727A mutation has a similar phenotype on AA release as the S505A mutation and Ser 727was found to be phosphorylated in tandem with Ser 505.
Although there is no inhibition of [Ca 2+] i release by U0126 and little effect on Ser 505phosphorylation, it is possible that MEK1 inhibition by U0126 prevents cPLA 2 translocation by another mechanism.
Diminution of AA release by MEK1/ERK is also independent of cPLA 2 phosphorylation on Ser 505.
Protein kinase pathways play major roles in cPLA 2 activation, and regulation by the mitogen-activated protein kinase kinase (MEK) /extracellular-signal regulated kinase (ERK) signaling pathway has received particular attention.
We have previously reported that p38 is also selectively activated in anisomycin-treated macrophages [ 21 ] . Importantly, pretreatment of cells for 30 min with anisomycin resulted in maintenance of the cPLA 2 gel shift in the presence of U0126 in unstimulated cells and in cells stimulated with ATP and 1 and 10 μM IONO (Fig.