Words similar to cpla

Example sentences for: cpla

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2 S505A translocates in CHO cells in response to ionophore, we were able to directly compare rates of translocation between cPLA 2 and cPLA 2 S505A to a physiological agonist and found no difference between translocation rates or intracellular targeting.
However, EGFP-cPLA 2 is functional since it dose-dependently catalyzes release of AA when expressed in cells that lack endogenous cPLA 2 , such as Sf9 cells [ 13 ] and immortalized mouse lung fibroblasts from cPLA 2 α knock-out mice [ 26 ] . In order to enhance AA release in cells containing endogenous cPLA
The effect of inhibition of the MEK1/ERK pathway by U0126 on translocation of cPLA 2 was investigated.
One explanation for the decrease in AA is that U0126 inhibits [Ca 2+] i mobilization in response to ATP or IONO, thereby preventing translocation of cPLA 2 . In chick ventricular myocytes, inhibition of MEK1/ERK by PD98059 inhibits zinterol-mediated AA release, but also inhibits zinterol-induced stimulation of [Ca 2+] i cycling in electrically stimulated cells [ 33 ] . In MDCK cells, extracellular ATP acts via P 2Y2 receptors to elicit an IP 3 -mediated [Ca 2+] i increase [ 34 ] and IONO acts to increase [Ca 2+] i by permeabilizing cell membranes to Ca 2+.
We also demonstrated that there was no difference in translocation rates or intracellular targeting between wild-type cPLA 2 and cPLA 2 S727A, which has the same phenotype as S505A with regard to AA release when transfected into cells.