Words similar to cpla

Example sentences for: cpla

How can you use “cpla” in a sentence? Here are some example sentences to help you improve your vocabulary:

To better understand the regulation of cPLA 2 by the MEK1/ERK pathway and Ca 2+, we investigated the effect of MEK inhibitors on AA release, cPLA 2 phosphorylation of Ser 505, cPLA 2 translocation kinetics, and [Ca 2+] i increase in Madin-Darby canine kidney (MDCK) cells.
We also demonstrated that there was no difference in translocation rates or intracellular targeting between wild-type cPLA 2 and cPLA 2 S727A, which has the same phenotype as S505A with regard to AA release when transfected into cells.
Phosphorylation of cPLA 2 on Ser 505has been hypothesized to play a role in Ca 2+-mediated translocation since Ser 505phosphorylation is required for cPLA 2 -mediated AA release in response to low-dose, but not high-dose, ionophore [ 22 ] . Translocation of cPLA 2 S505A in CHO cells has been reported in response to ionophore stimulation [ 25 ] , but the effect of Ser 505phosphorylation on the kinetics of translocation, targeting, and in response to a physiological agonist was not investigated.
Although one report has shown that cPLA
cPLA 2 -mediated AA release must be preceded by translocation of the enzyme to its membrane substrate which is a Ca 2+-dependent process and is a function of the calcium-dependent lipid-binding (C2) domain.