Words similar to cpla

Example sentences for: cpla

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In response to physiological agonists that elicit transient [Ca 2+] i changes, only a small fraction of the cPLA 2 translocates.
It is also possible that the alternative mechanism is due to phosphorylation of cPLA 2 on a novel site by a kinase that is downstream of the MEK1/ERK pathway or phosphorylation of a regulatory protein.
This is demonstrated by the results showing that inhibition of the MEK1/ERK pathway significantly blocks AA release but has no effect on [Ca 2+] i mobilization or cPLA 2 translocation and targeting.
Because cPLA 2 is a target of the MEK1/ERK signaling cascade, we assayed the effect of MEK1 inhibition by U0126 on cPLA 2 phosphorylation by analyzing gel shift of cPLA 2 . Phosphorylation of Ser 505results in a retardation of its electrophoretic mobility (gel shift) [ 13 16 ] . In unstimulated cells, EGFP-tagged and endogenous cPLA 2 were nearly completely gel shifted, indicating that most cPLA 2 was phosphorylated on Ser 505(Fig.
Protein kinase pathways play major roles in cPLA 2 activation, and regulation by the mitogen-activated protein kinase kinase (MEK) /extracellular-signal regulated kinase (ERK) signaling pathway has received particular attention.