Words similar to coa
Example sentences for: coa
How can you use “coa” in a sentence? Here are some example sentences to help you improve your vocabulary:
The fba -, pfkAB -, and tpiA - in silico deletion strains had a limited capability to synthesize glyceraldehyde 3-phosphate, 3-phosphoglycerate, phosphoenolpyruvate, pyruvate, acetyl-CoA, α-ketoglutarate, succinyl-CoA, oxaloacetate, and high-energy phosphate bonds in all phases, and were completely unable to synthesize many of the biosynthetic precursors in phases 46 (Table 1) ( tpi - in silico strain discussed below).
HMG CoA = 3-Hydroxy-3-methylgluatryl coenzyme A; MIRACL = Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering; LDL = low density lipoprotein; RR = relative risk; CI = confidence interval; HDL = high density lipoprotein; PTCA = percutaneous transluminal coronary angioplasty; CABG = coronary artery bypass graft; ECG = electrocardiogram; A-2-Z = Aggrastat to Zocor; ACS = acute coronary syndrome; PROVE IT = Pravastatin or Atorvastatin Evaluation and Infection Therapy.
Cpt1 transfers acyl residues from CoA to carnitine in the intermembrane space of the inner mitochondrial membrane, and has a regulatory role in controlling hepatic β-oxidation [ 50 ] . Cpt2 transfers carnitinoyl residues to CoA in the mitochondrial matrix for β-oxidation.
In the liver, intestine, adipose, and mammary gland, the cytoplasmic form synthesizes acetyl CoA for lipogenesis [ 46 ] . It is regulated by SREBP-1a, -1c- and -2, as well as SP1 and SP3 binding to GC-boxes; the promoter also contains an E-box [ 47 ] . It is down regulated with fasting, and induced with re-feeding; such dietary regulation does not exist in SREBP-1 knockout mice [ 48 ] . More generally, acyl CoA synthase is reported to be PPARα-activated [ 49 ] . The observed down regulation is consistent with less acetyl CoA available for the ACC reaction, as well as a plethora of other reactions.
This uses the building units in the form of activated derivatives, called coenzyme A (CoA) esters, so we speak of acetyl-CoA and malonyl-CoA, for example.
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