Words similar to choline
Example sentences for: choline
How can you use “choline” in a sentence? Here are some example sentences to help you improve your vocabulary:
The magnitude of this effect tended to be small (approximately 15%), presumably because free choline is a rapidly turning over metabolic intermediate that does not accumulate in cells (Fig.
Before the availability of antibodies against nicotinic acetylcholine receptors of dipteran flies, cholinergic pathways have been analyzed by more indirect methods, mainly by immunocytochemistry against choline acetyltransferase (ChAT), an enzyme of the acetylcholine metabolism [ 38, 39] or autoradiography of 125I-α-bungarotoxin binding [ 40, 41].
ACh content was determined by high performance liquid chromatography with an enzymatic reactor containing acetylcholinesterase and choline oxidase and an electrochemical detector using a commercial kit (Bioanalytical Systems, Inc.) based on the method of Potter et al.
5) indicating that choline generated by PLD1 was converted to ACh.
The available research regarding cognitive function and phytoestrogens suggests that large amounts of phytoestrogens, consumed as tofu, have an adverse influence on cognitive ability in men, where decreased brain weight, increased ventricular size and dementia have been reported [ 44 ] . In ovariectomized female rats, on the other hand, phytoestrogen treatments resulted in a dose-dependent improvement of VSM [ 45 ] . This improvement in cognitive ability in phytoestrogen treated females may be due in part to the increased presence of choline acetyltransferase messenger RNA in the frontal cortex, which has been shown to be associated with protection and enhancement of cognitive function [ 45 ] . Furthermore, we have shown that phytoestrogens significantly affect the brain calcium-binding protein calbindin (CALB), which acts as a buffer by binding intracellular calcium and plays an important role in mediating cell proliferation, programmed cell death (apoptosis), and neurotoxicity [ 48 49 50 51 52 ] . This neuroprotective mechanism via CALB appears to be important in neurological disorders such as Parkinson's disease and Huntington's disease [ 48 49 50 51 52 ] . Additionally, Cyclooxygenase-2 (COX-2) seems to play an important role in mediating functional neuronal maturation and responses to certain stimuli in the brain [ 53 54 55 ] . The expression of COX-2 is associated with key pathophysiologic events in Alzheimer's disease: deposition of beta-amyloid protein in neuritic plaques within the hippocampus and cortex [ 53 54 55 ] . Of particular importance to this study is the fact that COX-2 has been shown to be influenced by steroidal hormones [ 53 54 55 ] . Therefore, the expression of COX-2 in the frontal cortex may also be hormonally regulated and relevant to cognitive decline.
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