Words similar to choline
Example sentences for: choline
How can you use “choline” in a sentence? Here are some example sentences to help you improve your vocabulary:
Most of the previous studies on the physiological functions PLDs have concentrated on the role of its product, PA [ 7 ] . Our data show that PLD has a dual function in cholinergic cells, as the second product of its activity, choline, is used as a metabolic precursor of ACh, and suggest that this pathway may be regulated by the type of PLD isoform expressed in a particular class of cholinergic neurons.
Our previous results in cholinergic human neuroblastoma LA-N-2 cells indicated that the choline moiety from PC breakdown was released directly into the cytoplasm [ 4 ] and a kinetic study using [ 3H]choline in BHK cells also showed that choline was initially released inside the cells by PMA-activated PLD and then rapidly appeared in the medium [ 32 ] . Consistent with the latter study, we also observed a rise in the medium choline levels in SN56 cells transfected with either PLD1 or PLD2 and treated with PMA.
In control studies performed in the presence of choline (15 μM) in the medium PMA had no effect on ACh levels (data not shown), indicating that it did not stimulate the process of ACh synthesis but only the supply of choline.
Significantly, intracellular choline and ACh content were similarly decreased by the antisense oligonucleotides, indicating that PLD2-catalyzed hydrolysis of PC provides choline for ACh synthesis.
One of the two known genes for which allelic variation was identified within its coding region sequence was Slc5a7 . This encodes a high-affinity choline transporter expressed in the brain and spinal cord and may be considered a plausible candidate gene for underlying the QTL (see Discussion).
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