Words similar to cholesterol-rich

Example sentences for: cholesterol-rich

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In response to receptor activation, Syk becomes non-covalently associated with the BCR through tandem SH2 domains located in the amino terminal half of the protein [ 44 ] . Following engagement of the BCR, phosphorylation of specific tyrosine residues in immunoreceptor tyrosine-based activation motifs (ITAMs) found within the cytoplasmic tails of CD79a and CD79b provides docking sites for Syk localization [ 45 46 47 ] . The ability of phosphorylated ITAM peptides to selectively enhance Syk kinase activity in vitro suggests that recruitment of Syk to the receptor complex may serve to activate the kinase, in part, through allosteric changes in the structure of the Syk protein [ 44 48 49 ] . Upon activation, Syk and the receptor complex become localized in detergent-resistant cholesterol-rich membrane microdomains (lipid rafts), resulting in the segregation of the BCR complex from other membrane components [ 50 ] .