Words similar to cephalosporins

Example sentences for: cephalosporins

How can you use “cephalosporins” in a sentence? Here are some example sentences to help you improve your vocabulary:

The isolated organisms are becoming resistant to the commonly used antibiotics and cephalosporins may have to be prescribed in resistant cases.
All crystallographically characterized metallo-β-lactamases have a flexible amino acid chain that extends over the active site [ 37 42 44 45 46 47 48 49 ] . Previous NMR studies on CcrA have shown that this loop "clamps down" on substrate or inhibitor upon binding, and there is speculation that the distortion of substrate upon clamping down of the loop may drive catalysis [ 50 ] . The crystal structure of L1 showed that there is a large loop that extends over the active site, and modeling studies have predicted that two residues, Ile164 and Phe158, make significant contacts with large, hydrophobic substituents at the 2' or 6' positions on penicillins, cephalosporins, or carbapenems [ 37 ] . To test this prediction, Ile 164 and Phe158 were changed from large, hydrophobic residues to alanines to afford the I164A and F158A mutants.
Beta-lactamases have been widely investigated for their role in the metabolism of antibiotics including cephalosporins and penicillins.
The Tyr228 mutants exhibited < 4-fold change in k cat values for the cephalosporins tested (Table 3), suggesting that Tyr228 is not playing a large role in catalysis.
On the other hand, the S224D mutant exhibited 3- to 50-fold higher K m values and 2- to 20-fold lower k cat values for the cephalosporins tested.