Words similar to cephalosporins
Example sentences for: cephalosporins
How can you use “cephalosporins” in a sentence? Here are some example sentences to help you improve your vocabulary:
These bacteria become resistant by a number of mechanisms, such as producing enzymes that hydrolyze or inactivate the antibiotics, producing efflux pumps that transport the antibiotic out of the cell, or modifying their cell wall components so they no longer bind effectively to the antibiotics [ 1 2 3 ] . The most common, least expensive, and effective antibiotics are the β-lactam containing antibiotics, such as the penicillins, cephalosporins, and carbapenems [ 2 4 5 ] . These antibiotics are mechanism-based inhibitors of transpeptidase, a bacterial enzyme required for the production of a strong viable cell wall [ 6 7 ] . In response to the widespread use of β-lactam containing antibiotics, bacteria have acquired the ability to produce β-lactamases, which are enzymes that hydrolyze and inactivate β-lactam containing antibiotics.
When using the cephalosporins, nitrocefin, cefoxitin, and cephalothin, as substrates and the I164A mutant, there were 2- to 10-fold (only for cefoxitin) increases in K m and 2- to 4-fold increases in k cat observed (Table 3).
When cephalosporins were used as substrates, the Y228A and Y228F mutants exhibited K m values that were 6- to 45-fold higher than those observed for wild-type L1 (Table 3).
When the cephalosporins were used as substrates, the S224A and S224K mutants exhibited 2- to 4-fold changes in K m values (Table 3).
The isolated organisms are becoming resistant to the commonly used antibiotics and cephalosporins may have to be prescribed in resistant cases.
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