Words similar to cephalosporin-doxorubicin
Example sentences for: cephalosporin-doxorubicin
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For example, a cephalosporin-doxorubicin prodrug was 9-fold less toxic than free doxrubicin against tumor cells in vitro, but caused tumor regression when tested in tumor xenograft models [ 40 ] . A cephalosporin-vinca alkaloid prodrug was 5-fold less toxic than the free drug against tumor cells in vitro, but was highly effective in tumor xenograft models in vivo [ 41 ] . When taxol was conjugated to a cephalosporin, the resulting prodrug was approximately 10-fold less toxic than free taxol against tumor cells in vitro [ 36 ] . Thus, prodrug 2 has the potential to be useful in cancer treatment using the ADEPT approach.