Words similar to cephalosporin

Example sentences for: cephalosporin

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For example, a cephalosporin-doxorubicin prodrug was 9-fold less toxic than free doxrubicin against tumor cells in vitro, but caused tumor regression when tested in tumor xenograft models [ 40 ] . A cephalosporin-vinca alkaloid prodrug was 5-fold less toxic than the free drug against tumor cells in vitro, but was highly effective in tumor xenograft models in vivo [ 41 ] . When taxol was conjugated to a cephalosporin, the resulting prodrug was approximately 10-fold less toxic than free taxol against tumor cells in vitro [ 36 ] . Thus, prodrug 2 has the potential to be useful in cancer treatment using the ADEPT approach.
Herein, we report synthesis and preliminary cytotoxic effects of a prodrug comprised of a cephalosporin and a CC-1065 analogue (Figure 1).
This is the first report demonstrating synthesis of a prodrug comprised of a cephalosporin and a CC-1065 analogue.
All patients were treated with the current empirical standard of care for CAP i.e. combination of a third generation cephalosporin and a macrolide or flouroquinolone as monotherapy with necessary prescription adjustments after bacteriology results where applicable.
The use of cephalosporins in our study was less than that reported in the literature [ 20 21 ] . However, direct comparisons of cephalosporin utilization may not be appropriate as one of the studies [ 20 ] was carried out both inside and outside of health care facilities in Norway while the other study [ 21 ] was carried in a rural hospital.