Example sentences for: calcium-dependent

How can you use “calcium-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Besides inhibiting proteasome activity, the peptide aldehyde proteasome inhibitors have been also reported to repress certain lysosomal cysteine proteases and calpains [ 49 ] . The finding that MG-132 can obstruct the casein degrading activity of the calcium-dependent protease calpain [ 50 ] appears relevant to oocyte maturation.

  • Fibulin-1 has been reported two exhibit calcium-dependent self-association [ 40 44 ] . The two self-association sites map to type II EGF-like modules 5 and 6 and to a cryptic site in the amino-terminal region of fibulin-1 [ 40 44 ] .

  • cPLA 2 -mediated AA release must be preceded by translocation of the enzyme to its membrane substrate which is a Ca 2+-dependent process and is a function of the calcium-dependent lipid-binding (C2) domain.

  • Tetraethylammonium is known as a pore-occluding blocker of voltage-gated potassium channels [ 1 ] , but it also blocks other cationic channels such as calcium-dependent K +channels [ 2 3 ] and the nicotinic acetylcholine receptor [ 4 ] . TEA at 0.1 to 10 mM also inhibits osmotic water flux through human AQP1 channels expressed in Xenopus oocytes, decreasing the net swelling rate in hypotonic saline by 30-40% as compared to AQP1-expressing oocytes not treated with TEA [ 5 ] . This blocking effect on osmotic water flux was demonstrated to involve AQP1 channels specifically by using site-directed mutagenesis (tyrosine 186 to phenylalanine) to generate a Y186F AQP1 channel that is insensitive to block by TEA, but retains sensitivity to block by mercury.

  • An amino terminal, calcium-dependent lipid binding (CaLB or C2) domain regulates Ca 2+-mediated cPLA 2 translocation to intracellular membranes [ 9 ] . In vitro, membrane docking via the C2 domain is necessary and sufficient for catalysis and release of AA [ 10 ] . Binding of calcium ions by the cPLA 2 C2 domain is essential for the lipid association in vitro [ 11 12 ] and translocation in vivo [ 13 14 ] . In response to an increase in [Ca 2+] i , cPLA 2 translocates to the Golgi and ER, however translocation to Golgi occurs at a lower [Ca 2+] i [ 15 ] .


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