Example sentences for: calcium-dependent

How can you use “calcium-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Aggrecan and versican are aggregating proteoglycans that are key constituents found in the extracellular matrix [ 41 ] . Both proteoglycans contain amino-terminal hyaluronic acid-binding regions, central core glycosaminoglycan attachment domains, and carboxyl-terminal domains containing EGF-like modules (one in aggrecan and two in versican), C-type lectin like modules and complement regulatory protein-like modules [ 49 50 ] . Fibulin-1 exhibits calcium-dependent binding to the carboxyl-terminal domain of aggrecan and versican [ 41 ] . The binding site of aggrecan to fibulin-1 maps to the type II EGF-like modules 8-9 and the carboxyl-terminal domain of fibulin-1 [ 41 ] . The binding site of versican to fibulin-1 maps to the type II EGF-like modules 2-8 of fibulin-1 [ 41 ] .

  • Cathepsin B is a lysosomal cysteine protease, the expression of which is increased in different tumors, including human brain, lung, colon, and breast tumors [ 19 ] . Calpastatin is a physiological protease inhibitor that acts specifically on calpain, a calcium-dependent cysteine protease.

  • Tetraethylammonium is known as a pore-occluding blocker of voltage-gated potassium channels [ 1 ] , but it also blocks other cationic channels such as calcium-dependent K +channels [ 2 3 ] and the nicotinic acetylcholine receptor [ 4 ] . TEA at 0.1 to 10 mM also inhibits osmotic water flux through human AQP1 channels expressed in Xenopus oocytes, decreasing the net swelling rate in hypotonic saline by 30-40% as compared to AQP1-expressing oocytes not treated with TEA [ 5 ] . This blocking effect on osmotic water flux was demonstrated to involve AQP1 channels specifically by using site-directed mutagenesis (tyrosine 186 to phenylalanine) to generate a Y186F AQP1 channel that is insensitive to block by TEA, but retains sensitivity to block by mercury.

  • In the case of T cells, antigen stimulation elicits a calcium-dependent signaling pathway that results in the activation of calcineurin, which directly dephosphorylates NFATp in preparation for nuclear import [ 11, 22].

  • For instance, an action link (iconified as a wall plug) allows the calcium-dependent activation of calmodulin in Figure 4to inhibit the export of cyclin D1 from the nucleus in Figure 3. Identity links, on the other hand, allow models to share a common icon and its properties.


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