Words similar to calb
Example sentences for: calb
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In male and female rats from experiments 1 and 2, CALB and COX-2 levels in the frontal cortex and hippocampus (CALB only) were determined using Western blot analysis, as reported elsewhere [ 49 55 ] . In brief, homogenized samples (30 μg per lane for frontal cortex and hippocampus- by treatment) were resolved on 14% Tri-Glycine gels and transferred onto Millipore Immobilon-P membranes (Millipore, Bedford, MA, USA) by electroblotting.
Since reference memory is thought to be mediated in the frontal cortex and because males fed the Phyto-600 diet had decreased expression of CALB (a neuroprotectant factor) and increased COX-2 (an inflammatory factor prevalent in Alzheimer's disease) levels in this brain region compared to males fed the Phyto-free diet, these findings suggest that phytoestrogens, present in soy dietary sources, may alter VSM via there presence and action in the frontal cortex.
In females, similar to the CALB results above, there was no significant diet effect on COX-2 levels and the band intensities were almost identical to that of male Phyto-free values.
An amino terminal, calcium-dependent lipid binding (CaLB or C2) domain regulates Ca 2+-mediated cPLA 2 translocation to intracellular membranes [ 9 ] . In vitro, membrane docking via the C2 domain is necessary and sufficient for catalysis and release of AA [ 10 ] . Binding of calcium ions by the cPLA 2 C2 domain is essential for the lipid association in vitro [ 11 12 ] and translocation in vivo [ 13 14 ] . In response to an increase in [Ca 2+] i , cPLA 2 translocates to the Golgi and ER, however translocation to Golgi occurs at a lower [Ca 2+] i [ 15 ] .
Western analysis of the same frontal cortex samples (as performed for the CALB Western analysis) revealed significantly lower COX-2 levels in Phyto-free males compared to Phyto-600 males ( F (1,10) = 30.
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