Words similar to c-kit
Example sentences for: c-kit
How can you use “c-kit” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since the effect of Gleevec is mediated through inhibiting BCR-ABL tyrosine kinase, c-kit, and PDGF receptors, we are interested in the potential target for Gleevec effect in the lung cancer cells.
We have previously showed by immunohistochemical staining that in 54 primary non-small cell lung carcinoma specimens, expression of c-kit was weak and minimal, if any (Tang and Zhang, unpublished observation).
Gleevec was designed to inhibit the BCR-ABL tyrosine kinase, and it cross-reacts with c-kit and PDGFR [ 5 ] . In non-small cell lung cancer, BCR-ABL expression has never been reported, and it is unlikely that BCR-ABL fusion protein plays any role in lung cancer.
The c-kit receptor kinase and its ligand KL (kit ligand, stem cell factor) are encoded at the white spotting (W) and steel (Sl) loci of the mouse, respectively.
These results lead us to find an alternative target for Gleevec, because of the low expression level and low frequency of expression of c-kit in the lung cancer patients.