Words similar to c-kit
Example sentences for: c-kit
How can you use “c-kit” in a sentence? Here are some example sentences to help you improve your vocabulary:
We previously showed that non-small cell lung cancers express minimal (negligible) level of c-kit (Zhang, P., unpublished).
Gleevec has been shown to induce clinical, hematological and molecular remissions for CML patients [ 4 ] . It cross-reacts with two other important growth factor receptors containing tyrosine kinase domains, c-kit and PDGF receptors, that play important roles in growth and proliferation of a variety of cell types [ 5 ] . C-kit (also known as CD117) is frequently mutated in gastrointestinal stromal tumor (GIST), and the mutated c-kit shows higher tyrosine kinase activity.
We have studied the expression of c-kit (CD117) in the non-small cell lung cancer patients, and we found that approximately 13% of the tumor specimens were weakly positive for c-kit.
We have previously showed by immunohistochemical staining that in 54 primary non-small cell lung carcinoma specimens, expression of c-kit was weak and minimal, if any (Tang and Zhang, unpublished observation).
These results lead us to find an alternative target for Gleevec, because of the low expression level and low frequency of expression of c-kit in the lung cancer patients.
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