Words similar to c-kit

Example sentences for: c-kit

How can you use “c-kit” in a sentence? Here are some example sentences to help you improve your vocabulary:

Gleevec has been shown to induce clinical, hematological and molecular remissions for CML patients [ 4 ] . It cross-reacts with two other important growth factor receptors containing tyrosine kinase domains, c-kit and PDGF receptors, that play important roles in growth and proliferation of a variety of cell types [ 5 ] . C-kit (also known as CD117) is frequently mutated in gastrointestinal stromal tumor (GIST), and the mutated c-kit shows higher tyrosine kinase activity.
Therefore it is unlikely that Gleevec exerts the effect, if any, through c-kit on non-small cell lung cancer.
Since the effect of Gleevec is mediated through inhibiting BCR-ABL tyrosine kinase, c-kit, and PDGF receptors, we are interested in the potential target for Gleevec effect in the lung cancer cells.
Gleevec was designed to inhibit the BCR-ABL tyrosine kinase, and it cross-reacts with c-kit and PDGFR [ 5 ] . In non-small cell lung cancer, BCR-ABL expression has never been reported, and it is unlikely that BCR-ABL fusion protein plays any role in lung cancer.
We have previously showed by immunohistochemical staining that in 54 primary non-small cell lung carcinoma specimens, expression of c-kit was weak and minimal, if any (Tang and Zhang, unpublished observation).