Example sentences for: c-kit

How can you use “c-kit” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The c-kit receptor kinase and its ligand KL (kit ligand, stem cell factor) are encoded at the white spotting (W) and steel (Sl) loci of the mouse, respectively.

  • Therefore it is unlikely that Gleevec exerts the effect, if any, through c-kit on non-small cell lung cancer.

  • These results lead us to find an alternative target for Gleevec, because of the low expression level and low frequency of expression of c-kit in the lung cancer patients.

  • We have studied the expression of c-kit (CD117) in the non-small cell lung cancer patients, and we found that approximately 13% of the tumor specimens were weakly positive for c-kit.

  • Gleevec has been shown to induce clinical, hematological and molecular remissions for CML patients [ 4 ] . It cross-reacts with two other important growth factor receptors containing tyrosine kinase domains, c-kit and PDGF receptors, that play important roles in growth and proliferation of a variety of cell types [ 5 ] . C-kit (also known as CD117) is frequently mutated in gastrointestinal stromal tumor (GIST), and the mutated c-kit shows higher tyrosine kinase activity.


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