Words similar to c-myc
Example sentences for: c-myc
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Although its role has remained controversial, it is involved in the increase of immediate early genes such as c-myc [ 63 ] , which is upstream of cyclin D synthesis and necessary for cell division [ 64 ] . In humans, ProTα is coded by a gene family of six members.
IGF-I can prevent c-myc -induced apoptosis in rat-l fibroblasts, and neuronal apoptosis due to serum-starvation.
In addition to its effects on mRNA of c-myc and p53, RU486 significantly increased that of the oncogene mdm2 by approximately 20% (Fig 2B).
Similarly to nuclear receptors and to other transcription factors, STAT proteins can interact with coactivators to modulate their transcriptional activity [ 9 10 11 12 ] . Other reports have shown direct interactions between several members of the JAK/STAT signaling pathway with SHRs [ 13 14 15 16 ] . Stat3 is one of the seven members of the STAT family of proteins that has been shown to modulate the expression of several genes related to control cell cycle, proliferation and apoptosis, such as Cyclin D1, c-myc, and Bcl-xL, respectively [ 17 ] . Accordingly, alterations in the activity of STAT3 have been associated with cell transformation and cancer progression [ 18 19 20 ] .
The effects of PGs on cell proliferation and collagen production have been widely studied in different cell types [ 13 14 15 16 17 26 ] . TXA 2 has been studied extensively because of its apparent role in atherosclerosis, due to its prothrombotic and mitogenic activities on vascular smooth muscle cells [ 15 16 ] . These mitogenic effects are potentiated by growth factors [ 15 16 27 28 ] . In vascular smooth muscle cells TXA 2 stimulates synthesis of bFGF and increases the expression of the proto-oncogenes c-fos , c-myc , and egr-1 , which are associated with entry into the cell growth cycle [ 15 ] . In addition, TXA 2 increases proliferation of fibroblasts [ 13 ] and smooth muscle-like glomerular mesangial cells [ 14 ] .
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