Words similar to c-myc

Example sentences for: c-myc

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Interestingly, mesothelin expression is induced in lung, ovarian, and pancreatic carcinomas where constitutive activation of Wnt signaling is caused by stabilizing mutations in beta-catenin [ 27 28 41 42 43 44 ] . The induction of mesothelin in these carcinomas may be due to misregulation of Wnt signaling as are other targets of the Wnt pathway, c-myc and cyclin D1.
SMAD4 (DPC4) is essential for this TGFβ 1 signaling and transcriptional activation process [ 16 ] . In epithelial cells, TGFβ 1 decreases c-myc, cdc2 and cyclin D1 expression, and it increases the expression of c-jun and c-fos [ 17 18 19 20 21 22 23 ] . Activation of the TGFβ 1 signal pathway in epithelial cells leads to an increased expression of the cell cycle inhibitors p21 WAF1and p15 Ink4band to a release of formerly sequestered p27 KIP [ 24 25 26 ] . It is assumed that the cooperative action of these cell cycle inhibitors results in the growth arrest mentioned above, although p15 Ink4bdoes not seem to be necessary in this regard.
In addition to its effects on mRNA of c-myc and p53, RU486 significantly increased that of the oncogene mdm2 by approximately 20% (Fig 2B).
Though c-myc is located on a region that both CGMA and CGH identify as frequently gained, c- myc 's expression is increased more than twofold in less than 6% of the samples.
For example, the c-myc oncogene has been postulated to drive selection for frequent chromosome 8q amplification.