Words similar to c-fos
Example sentences for: c-fos
How can you use “c-fos” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since Elk-1 and p35-C/EBPβ synergize in transactivation of SRF-dependent transcription using a GAL4-dependent promoter, we next tested if Elk-1 and p35-C/EBPβ could also synergize in transactivation of a native SRF binding site, namely the c-fos SRE.
The protein product of this gene is a member of the activating protein-1 (AP-1) family [ 19 ] , which upon binding to either c-fos or fos B protein form a complex that have high affinity to AP-1 binding concensus sequence [ 20 ] . A wide variety of chemicals, including growth factors, and tumor promotors increase the expression of this gene in various cell types [ 21 ] . Compared to untransfected keratinocytes, JunB-transfected cells grew more rapidly, and were highly invasive in an in vitro assay [ 22 ] . Therefore, the increased hepatic levels of junB gene, in mice treated with RU486, was expected to reflect an uncontrolled hepatocellular growth in these animals.
Another transcription factor that is involved in regulation of the c-fos SRE is CCAAT/Enhancer binding protein-beta (C/EBPβ).
This report demonstrates a new model for c-fos SRE activation in response to Ras-dependent signaling pathways.
There is most likely a large protein complex assembled at the SRE composed of regulated transcription factors, coactivators, and the basal transcriptional machinery, resulting in rapid transcription of the c-fos gene in response to mitogenic stimulation.