Words similar to c-fos

Example sentences for: c-fos

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Another transcription factor that is involved in regulation of the c-fos SRE is CCAAT/Enhancer binding protein-beta (C/EBPβ).
SMAD4 (DPC4) is essential for this TGFβ 1 signaling and transcriptional activation process [ 16 ] . In epithelial cells, TGFβ 1 decreases c-myc, cdc2 and cyclin D1 expression, and it increases the expression of c-jun and c-fos [ 17 18 19 20 21 22 23 ] . Activation of the TGFβ 1 signal pathway in epithelial cells leads to an increased expression of the cell cycle inhibitors p21 WAF1and p15 Ink4band to a release of formerly sequestered p27 KIP [ 24 25 26 ] . It is assumed that the cooperative action of these cell cycle inhibitors results in the growth arrest mentioned above, although p15 Ink4bdoes not seem to be necessary in this regard.
Activation of ERK1 and ERK2, the major components of the MAPK pathway, presumably induces shear-specific transcription factors, such as c-fos/c-jun and NFκB, ultimately leading to changes in gene expression [ 30, 31].
These results suggest a cooperative role between the TCF and C/EBPβ transcription factors in regulation of the c-fos SRE in response to Ras-dependent signaling pathways.
In contrast, preincubation with α V - and β 6 -blocking antibodies curbed the TGFβ 1 -induced regulation of p21/WAF1, p27, c-fos, and the p21Ras and ERK1/2 activation, verifying that the binding of TGFβ 1 to the α V β 6 integrin is a prerequisite for the activation of the signal pathway via the α V β 6 integrin.