Words similar to c-fos
Example sentences for: c-fos
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The protein product of this gene is a member of the activating protein-1 (AP-1) family [ 19 ] , which upon binding to either c-fos or fos B protein form a complex that have high affinity to AP-1 binding concensus sequence [ 20 ] . A wide variety of chemicals, including growth factors, and tumor promotors increase the expression of this gene in various cell types [ 21 ] . Compared to untransfected keratinocytes, JunB-transfected cells grew more rapidly, and were highly invasive in an in vitro assay [ 22 ] . Therefore, the increased hepatic levels of junB gene, in mice treated with RU486, was expected to reflect an uncontrolled hepatocellular growth in these animals.
Another transcription factor that is involved in regulation of the c-fos SRE is CCAAT/Enhancer binding protein-beta (C/EBPβ).
SMAD4 (DPC4) is essential for this TGFβ 1 signaling and transcriptional activation process [ 16 ] . In epithelial cells, TGFβ 1 decreases c-myc, cdc2 and cyclin D1 expression, and it increases the expression of c-jun and c-fos [ 17 18 19 20 21 22 23 ] . Activation of the TGFβ 1 signal pathway in epithelial cells leads to an increased expression of the cell cycle inhibitors p21 WAF1and p15 Ink4band to a release of formerly sequestered p27 KIP [ 24 25 26 ] . It is assumed that the cooperative action of these cell cycle inhibitors results in the growth arrest mentioned above, although p15 Ink4bdoes not seem to be necessary in this regard.
c-fos expression peaked at 100 fold over unstimulated levels at 2 hours following EGF addition.
Blots were incubated with antibodies to human cyclin H, cdk7, cyclin A, p21 WAF1/Cip1, p27 Kip1, EGFR, activated and total ERK1, c-fos, Fra-1, c-jun, JunB, or β-actin (Santa Cruz Biotechnology) for 16 hours at 4°C.
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