Example sentences for: c-crk

How can you use “c-crk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Immunoprecipitation of endogenous c-crk showed association with endogenous Cas (Fig.

  • Immunoprecipitating endogenous c-crk and probing for associated C3G demonstrated that C3G association with c-crk was reduced in the presence of the tyrosine phosphorylated chimera (Fig.

  • Tyrosine phosphorylated Cas SD acts as a decoy for v-crk and endogenous c-crk

  • To determine if the tyrosine phosphorylated chimera could compete with endogenous Cas for binding to endogenous c-crk, we transfected either the isolated attenuated Src kinase domain as control, or the tyrosine phosphorylated Cas substrate domain (Src*/Cas(SD)) into Cos-7 cells, and immunoprecipitated endogenous c-crk (Fig.

  • Thus c-crk interacts constitutively with downstream effectors such as C3G via its SH3 domains, and interacts in a phosphotyrosine dependent fashion with tyrosine phosphorylated receptors using its SH2 domain [ 39 ] . To analyze downstream signals regulated by these adaptor proteins, investigators have developed methods that target them to distinct cellular membrane compartments by using heterologous targeting sequences.


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