Example sentences for: c-crk

How can you use “c-crk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These data suggest that the tyrosine phosphorylated Cas chimera perturbs signaling via v-crk and probably via endogenous c-crk to affect the activation of the JNK pathway.

  • To determine if the tyrosine phosphorylated chimera could compete with endogenous Cas for binding to endogenous c-crk, we transfected either the isolated attenuated Src kinase domain as control, or the tyrosine phosphorylated Cas substrate domain (Src*/Cas(SD)) into Cos-7 cells, and immunoprecipitated endogenous c-crk (Fig.

  • Tyrosine phosphorylated Cas SD acts as a decoy for v-crk and endogenous c-crk

  • As the tyrosine phosphorylated Cas substrate domain acts as a dominant negative for v-crk mediated transformation and JNK activation, and can also interact with v-crk and c-crk (data not shown), we wanted to determine if it could compete for binding of v- and c-crk to endogenous Cas.

  • These data suggest that the tyrosine phosphorylated substrate domain of Cas acts as a decoy for binding to v- and c-crk thereby interfering with signaling to JNK activation and transformation.


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