Words similar to c-crk
Example sentences for: c-crk
How can you use “c-crk” in a sentence? Here are some example sentences to help you improve your vocabulary:
Immunoprecipitation of endogenous c-crk showed association with endogenous Cas (Fig.
Immunoprecipitating endogenous c-crk and probing for associated C3G demonstrated that C3G association with c-crk was reduced in the presence of the tyrosine phosphorylated chimera (Fig.
Tyrosine phosphorylated Cas SD acts as a decoy for v-crk and endogenous c-crk
To determine if the tyrosine phosphorylated chimera could compete with endogenous Cas for binding to endogenous c-crk, we transfected either the isolated attenuated Src kinase domain as control, or the tyrosine phosphorylated Cas substrate domain (Src*/Cas(SD)) into Cos-7 cells, and immunoprecipitated endogenous c-crk (Fig.
Thus c-crk interacts constitutively with downstream effectors such as C3G via its SH3 domains, and interacts in a phosphotyrosine dependent fashion with tyrosine phosphorylated receptors using its SH2 domain [ 39 ] . To analyze downstream signals regulated by these adaptor proteins, investigators have developed methods that target them to distinct cellular membrane compartments by using heterologous targeting sequences.