Words similar to c-crk

Example sentences for: c-crk

How can you use “c-crk” in a sentence? Here are some example sentences to help you improve your vocabulary:

Furthermore, we found that the tyrosine phosphorylated Cas SD competed effectively with the endogenous Cas for binding to v-crk and endogenous c-crk, while not affecting tyrosine phosphorylation of proposed upstream proteins such as Fak and endogenous Cas.
To determine if the tyrosine-phosphorylated Cas SD chimera affected other signaling pathways, we tested whether the association between c-crk and C3G was affected in NIH3T3 cells expressing the chimera (Fig.
Thus c-crk interacts constitutively with downstream effectors such as C3G via its SH3 domains, and interacts in a phosphotyrosine dependent fashion with tyrosine phosphorylated receptors using its SH2 domain [ 39 ] . To analyze downstream signals regulated by these adaptor proteins, investigators have developed methods that target them to distinct cellular membrane compartments by using heterologous targeting sequences.
These data suggest that the tyrosine phosphorylated substrate domain of Cas acts as a decoy for binding to v- and c-crk thereby interfering with signaling to JNK activation and transformation.
As the tyrosine phosphorylated Cas substrate domain acts as a dominant negative for v-crk mediated transformation and JNK activation, and can also interact with v-crk and c-crk (data not shown), we wanted to determine if it could compete for binding of v- and c-crk to endogenous Cas.