Words similar to btk

Example sentences for: btk

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In addition, we have found that kinase inactive Btk can reconstitute BCR-induced ERK MAPK activation, but not PLCγ2 phosphorylation (Tomlinson, Bolen and Johnston, unpublished data).
However Btk:ER was clearly able to induce sustained ERK activity and this, coupled with the findings that in Btk-deficient cells the sustained response is impaired [ 9], suggest that Btk activation may be responsible for the prolonged ERK activation normally detected following BCR cross-linking.
Btk is thought to be activated upon BCR cross-linking by a two-step mechanism involving phosphatidylinositol (PI) 3-kinase and the Src family PTK Lyn (reviewed in references [ 4, 5, 6]).
In contrast to the pro-apoptotic role for Btk in DT40 cells, Btk appears to play an anti-apoptotic role in mature B cells in vivo . The mechanism may involve Btk-dependent activation of the transcription factor NF-κ B [ 7, 10] and subsequent upregulation of the anti-apoptotic protein Bcl-X L [ 39, 40].
These data agree both with two-hybrid experiments and in vitro filter binding assays that have demonstrated specific binding of the proline-rich region near the amino-terminus of BTK and Tec to the SH3 domains of the Src family kinases Fyn, Lyn and Hck [ 22, 25, 26].