Words similar to btk

Example sentences for: btk

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The slow Btk:ER kinetics are consistent with data derived from Btk-deficient cells, in which sustained BCR-induced PLCγ2 phosphorylation, calcium mobilization and MAPK activation are impaired, but the initial responses are relatively normal and appear to be driven by Syk activity (reviewed in reference [ 15]).
Btk is the prototypical member of the Tec family of non-receptor protein tyrosine kinases (PTKs) that includes Bmx, Itk, Tec and Txk [ 2, 3].
In the present study, while we cannot rule out the possibility that Btk:ER activates PLCγ2 in combination with other uncharacterized pathways, our data strongly support the Btk/PLCγ2 signalosome model by showing that PLCγ2 is absolutely required for Btk:ER-induced calcium, MAPK and apoptosis responses.
In particular, it is not clear if the capacity of Btk to connect to downstream signaling pathways, such as calcium mobilization, MAPK activation and apoptosis, is mediated through PLCγ2 or whether it can occur via other pathways.
In Fig 3A, Btk-deficient cells that express either WT or kinase inactive Btk:ER were treated with 4-HT, or PMA as a positive control, and ERK activity was assessed by immune complex kinase assay using MBP as an exogenous substrate.