Words similar to btk

Example sentences for: btk

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In order to determine if Btk:ER was active in vivo , cells were treated with vehicle control, 4-HT or anti-μ, and the phosphorylation status of cellular proteins and Btk:ER were analysed by Western blotting (Fig 1C).
Phosphopeptide mapping and mutational analyses of Btk have identified Y551 in the activation loop of the kinase domain as the major Src-transphosphorylation site.
This suggests that Btk can function independently of catalytic activity, perhaps as an adapter protein, and that Btk-induced PLCγ2 phosphorylation is not essential for PLCγ2 activation.
Btk was originally identified in B cells but is now known to be expressed in most leukocytes with the exception of T cells and NK cells.
Upon BCR stimulation, Btk is thought to be recruited to PLCγ2 via the adapter protein BLNK, as BLNK can associate with the SH2 domains of both PLCγ2 [ 31, 32] and Btk [ 33].