Words similar to btk-deficient

Example sentences for: btk-deficient

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Biochemical analyses of Btk-deficient cells have suggested that PLCγ2 is a downstream substrate of Btk [ 8, 11].
BCR-induced activation of the ERK and JNK MAPK pathways is impaired in Btk-deficient DT40 cells, but p38 MAPK activation is unaffected [ 9].
In particular, we have found that Btk-deficient DT40 cells reconstituted with Txk, an atypical Tec family PTK, fail to undergo BCR-induced JNK activation (Tomlinson and Johnston, unpublished data) and apoptosis [ 13], but ERK activation is relatively normal [ 13].
Btk-deficient cells expressing either WT or kinase inactive Btk:ER were treated with 4-HT or anti-μ and PLCγ2 phosphorylation was analysed by Western blotting (Fig 2A).
This partially impaired function of Btk:ER in parental cells compared to Btk-deficient cells, in eliciting a biological response, may be due to the presence of endogenous chicken Btk that could compete with Btk:ER for optimal subcellular location.