Words similar to btk-deficient

Example sentences for: btk-deficient

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However Btk:ER was clearly able to induce sustained ERK activity and this, coupled with the findings that in Btk-deficient cells the sustained response is impaired [ 9], suggest that Btk activation may be responsible for the prolonged ERK activation normally detected following BCR cross-linking.
In Fig 3C, Btk-deficient cells expressing either WT or kinase inactive Btk:ER were treated with 4-HT and/or anti-μ for 24 hours.
This partially impaired function of Btk:ER in parental cells compared to Btk-deficient cells, in eliciting a biological response, may be due to the presence of endogenous chicken Btk that could compete with Btk:ER for optimal subcellular location.
As a further control, 4-HT treatment of Btk-deficient cells, expressing Btk without the ER domain, did not induce PLCγ2 phosphorylation (Fig 2B, lanes 9-11).
In Fig 3A, Btk-deficient cells that express either WT or kinase inactive Btk:ER were treated with 4-HT, or PMA as a positive control, and ERK activity was assessed by immune complex kinase assay using MBP as an exogenous substrate.