Words similar to btk-deficient

Example sentences for: btk-deficient

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As a further control, 4-HT treatment of Btk-deficient cells, expressing Btk without the ER domain, did not induce PLCγ2 phosphorylation (Fig 2B, lanes 9-11).
This is in contrast to the Btk-deficient cells analysed earlier (Fig 3), where 4-HT and anti-μ yielded an equivalent apoptotic response.
However, in the context of signaling through the BCR, we surprisingly found that kinase inactive Btk:ER could reconstitute calcium mobilization in these Btk-deficient cells (Fig 2C).
BCR-induced activation of the ERK and JNK MAPK pathways is impaired in Btk-deficient DT40 cells, but p38 MAPK activation is unaffected [ 9].
In particular, we have found that Btk-deficient DT40 cells reconstituted with Txk, an atypical Tec family PTK, fail to undergo BCR-induced JNK activation (Tomlinson and Johnston, unpublished data) and apoptosis [ 13], but ERK activation is relatively normal [ 13].