Words similar to btk-deficient

Example sentences for: btk-deficient

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However, in the context of signaling through the BCR, we surprisingly found that kinase inactive Btk:ER could reconstitute calcium mobilization in these Btk-deficient cells (Fig 2C).
BCR-induced activation of the ERK and JNK MAPK pathways is impaired in Btk-deficient DT40 cells, but p38 MAPK activation is unaffected [ 9].
In Fig 3A, Btk-deficient cells that express either WT or kinase inactive Btk:ER were treated with 4-HT, or PMA as a positive control, and ERK activity was assessed by immune complex kinase assay using MBP as an exogenous substrate.
The Btk:ER constructs were transfected into Btk-deficient DT40 chicken B cells and stable clones were selected that expressed equivalent levels of Btk:ER.
Btk-deficient B cells are defective in BCR-induced PLCγ2 phosphorylation and calcium mobilization [ 8, 11].