Words similar to btk-deficient

Example sentences for: btk-deficient

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Btk-deficient cells expressing either WT or kinase inactive Btk:ER were treated with 4-HT or anti-μ and PLCγ2 phosphorylation was analysed by Western blotting (Fig 2A).
The Btk:ER constructs were transfected into Btk-deficient DT40 chicken B cells and stable clones were selected that expressed equivalent levels of Btk:ER.
However Btk:ER was clearly able to induce sustained ERK activity and this, coupled with the findings that in Btk-deficient cells the sustained response is impaired [ 9], suggest that Btk activation may be responsible for the prolonged ERK activation normally detected following BCR cross-linking.
Parental DT40 cells were considered a better control than the Btk-deficient cells used previously (Figs 1-3), as both PLCγ2-deficient and parental cells express endogenous chicken Btk.
Btk-deficient B cells are defective in BCR-induced PLCγ2 phosphorylation and calcium mobilization [ 8, 11].