Words similar to btk-deficient

Example sentences for: btk-deficient

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The Btk:ER constructs were transfected into Btk-deficient DT40 chicken B cells and stable clones were selected that expressed equivalent levels of Btk:ER.
This is in contrast to the Btk-deficient cells analysed earlier (Fig 3), where 4-HT and anti-μ yielded an equivalent apoptotic response.
In Fig 3A, Btk-deficient cells that express either WT or kinase inactive Btk:ER were treated with 4-HT, or PMA as a positive control, and ERK activity was assessed by immune complex kinase assay using MBP as an exogenous substrate.
In particular, we have found that Btk-deficient DT40 cells reconstituted with Txk, an atypical Tec family PTK, fail to undergo BCR-induced JNK activation (Tomlinson and Johnston, unpublished data) and apoptosis [ 13], but ERK activation is relatively normal [ 13].
BCR-induced activation of the ERK and JNK MAPK pathways is impaired in Btk-deficient DT40 cells, but p38 MAPK activation is unaffected [ 9].